GENETIC TIPS THE QUESTION: In the Western blot shown here, proteins were extracted from red blood cells obtained from tissue samples at different stages of human development. An equal amount of total cellular proteins was added to each lane. The primary antibody recognizes the B-globin polypeptide that is found in the hemoglobin protein. Explain these results. Lane 1: Embryonic red blood cells 2 3 Lane 2: Fetal red blood cells Lane 3: Newborn red blood cells Lane 4: Adult red blood cells
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- Question -The FDA has authorized the use of direct-to-consumer testing for three mutations in BRCA genes that elevate cancer risk, but cautions that a negative result does not rule out increased cancer risk. How can this be true? A. It is impossible to trust companies that are selling genetic tests. B. They have a conflict of interest, and so the tests should be used for entertainment value only C. These tests are not highly accurate, and false negatives are possible. Individuals with a family history should have a negative result confirmed with a different test to be sure they are truly at low risk of developing cancer There are more ways to get cancer than a mutation in the BRCA gene. D. The test only detects three out of more than 1,000 known BRCA mutations. This means a negative result does not rule out the possibility that an individual carries other BRCA mutations that increase cancer risk..Please explain it simply, and don't over-explain. Thanks! A. How can DNA be used to pass on inheritable material & make proteins?Question:- The success of renal transplantation depends on three human histocompatibility genes, HLA-A, HLA-B and HLA-C, which must match between the donor and the receiver. A single mismatch may cause the kidney rejection. Each gene has multiple co-dominant alleles. These three genes are located very close to each other on chromosome 6, so that the recombination rate is very low (below 1%). The father has the following genotype: A1, A2, B24, B10, Cw4 and Cw7 and the mother is A1, A1, B11, B7, Cw5 and Cw8. Their first boy is A1, A1, B24, B11, Cw7 and Cw8. What is the probability that the second child is compatible with his/her brother?
- QUESTION :-Why is it important to validate cell research with translational potential in animal and human studies? a. Cell cultures are often transformed and may no longer function in a physiological manner. b.Humans are complex systems and may not behave in the same way as a single cell. c. Genetic and epigenetic variation in the population may impact the findings. d.All of the aboveGene Expression and the Impact of a Mutation. Can someone help me to answer the question 8 and 9, please? 8. How has the mutation altered the polypeptide? Is the function of the hemoglobin molecule (which includes 2 ẞ-globin polypeptides and 2 a-globin polypeptides) impaired? (Read your book to learn more about sickle cell disease.) 9. What is the relationship between the genotype in this case and the individual's phenotype? asap pleasegenetics question please explain We know that multiple genes (some with many different alleles) contribute to skin color, but genes alone donot account for the diversity of pigmentation we see among humans; environmental factors play a role. b) Propose an explanation for how one of these factors could alter the expression of skin color genes.
- Genetics in Practice case studies are critical-thinking exercises that allow you to apply your new knowledge of human genetics to real-life problems. Case study Michelle was a 42-year-old woman who had declined counselling and amniocentesis at 16 weeks of pregnancy but was referred for genetic counseling after an abnormal ultrasound at 20 weeks of gestation. After the ultrasound, a number of findings suggested a possible chromosome abnormality in the fetus. The ultrasound showed swelling under the skin at the back of the fetuss neck; shortness of the femur, humerus, and ear length; and underdevelopment of the middle section of the fifth finger. Michelles physician performed an amniocentesis and referred her to the genetics program. Michelle and her husband did not want genetic counseling before receiving the results of the cytogenetic analysis. This was Michelles third pregnancy; she and her husband, Mike, had a 6-year-old daughter and a 3-year-old son. At their next session, the counselor informed the couple that the results revealed trisomy 21, explored their understanding of Down syndrome, and elicited their experiences with people with disabilities. She also reviewed the clinical concerns revealed by the ultrasound and associated anomalies (mild to severe intellectual disability, cardiac defects, and kidney problems). The options available to the couple were outlined. They were provided with a booklet written for parents making choices after the prenatal diagnosis of Down syndrome. After a week of careful deliberation with their family, friends, and clergy, they elected to terminate the pregnancy. Do you think that this couple had the right to terminate the pregnancy in light of the prenatal diagnosis? If not, under what circumstance would a couple have this right? What other options were available to the couple?IPSCs are nearly identical to human embryonic stem cells in terms of gene expression, but there may be other ways in which they are not equivalent. For example, the telomeres of IPSCs often vary in length, with many IPSCs cells having telomeres shorter than those of embryonic. How might shortened telomeres affect the life-span of IPSCs or of differentiated cells derived from them?Genetic application problems Two men (Father 1 and Father 2) claim in court the paternity of a child, whose blood group is 0. The mother is from group A, while the possible father 1 is from B and the possible father 2 is from AB. Please explain if this information can be used to indicate which of them is not your father. Come up with possible genotypes for the child, mother, and parents. Explain...
- Question: Explain how epigenetic marks and genomic imprinting are related. Provide a drawing to illustrate your point.Whole-exome sequencing (WES) is helping physicians diagnosea genetic condition that has defied diagnosis by traditionalmeans. The implication here is that exons in the nucleargenome are sequenced in the hopes that, by comparison withthe genomes of nonaffected individuals, a diagnosis might berevealed. What are the strengths and weaknesses of this approach?Topic: Recombinant pharmaceuticals (for the production of insulin, human growth hormone or blood clotting factors) Question Describe the molecular genetics process using proper scientific terminology. Describe the steps that are involved. How is it performed?