Hemoglobin S homozygotes who are severely anemic often have elevated levels of 2,3-bisphosphoglycerate (BPG) in their erythrocytes. Is this a beneficial effect? Yes, unless the person homozygous for HbS is pregnant. It might be initially beneficial, since the increased [BPG] will help to deliver more oxygen to the tissues. No, since the increased [BPG] will cause more sickling. This effect is neither beneficial nor harmful: BPG has nothing to do with sickle cell anemia. No, since the increased [BPG] decrease the hydrophobicity of the red blood cell making it more difficult for oxygen to diffuse into the cell.

Human Physiology: From Cells to Systems (MindTap Course List)
9th Edition
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Lauralee Sherwood
Chapter11: The Blood
Section: Chapter Questions
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Hemoglobin S homozygotes who are severely anemic often have elevated levels of
2,3-bisphosphoglycerate (BPG) in their erythrocytes. Is this a beneficial effect?
Yes, unless the person homozygous for HbS is pregnant.
It might be initially beneficial, since the increased [BPG] will help to deliver more
oxygen to the tissues.
No, since the increased [BPG] will cause more sickling.
This effect is neither beneficial nor harmful: BPG has nothing to do with sickle
cell anemia.
No, since the increased [BPG] decrease the hydrophobicity of the red blood cell
making it more difficult for oxygen to diffuse into the cell.
Transcribed Image Text:Hemoglobin S homozygotes who are severely anemic often have elevated levels of 2,3-bisphosphoglycerate (BPG) in their erythrocytes. Is this a beneficial effect? Yes, unless the person homozygous for HbS is pregnant. It might be initially beneficial, since the increased [BPG] will help to deliver more oxygen to the tissues. No, since the increased [BPG] will cause more sickling. This effect is neither beneficial nor harmful: BPG has nothing to do with sickle cell anemia. No, since the increased [BPG] decrease the hydrophobicity of the red blood cell making it more difficult for oxygen to diffuse into the cell.
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