Hormone Concentration (nM) Protein 1 Protein 2 Protein 3 0.2 0.048 0.29 0.17 0.5 0.11 0.5 0.33 1 0.2 0.67 0.5 4 0.5 0.89 0.9 10 0.71 0.95 0.91 20 0.83 0.97 0.95 50 0.93 0.99 0.98
Hormone Concentration (nM) Protein 1 Protein 2 Protein 3 0.2 0.048 0.29 0.17 0.5 0.11 0.5 0.33 1 0.2 0.67 0.5 4 0.5 0.89 0.9 10 0.71 0.95 0.91 20 0.83 0.97 0.95 50 0.93 0.99 0.98
Biology: The Unity and Diversity of Life (MindTap Course List)
14th Edition
ISBN:9781305073951
Author:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Chapter34: Endocrine Control
Section: Chapter Questions
Problem 2SQ: A __________ is synthesized from amino acids and cannot diffuse across the plasma membrane. a,...
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Question
Ligand binding to proteins may occur with varying strengths; some ligands bind tightly to proteins while others bind less tightly. The strengths of reversible binding are determined experimentally by varying concentrations of ligands, and measuring the saturation of the protein in the various ligand concentrations.
One such laboratory study investigated the binding of a hormone to three different receptor proteins in the cell membrane. The data collected are shown in the table below
1) Which of the proteins demonstrate the tightest/strongest binding of the hormone? Which demonstrates the least
tight binding of the hormone? What is the basis for your answer?
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