How is it possible for the GABA activated chloride channel (GABA-A receptor) to switch the direction of ion flow during development? This occurs when the KCC2 transporter becomes active and transports chloride ions out of the cell to lower the chloride concentration inside the cell from 25mM to 4mM. Explain your answer using thermodynamic principles of ion flow through ion channels (passive diffusion while the channel is open). Hint: calculate deltaG (free energy change), R=8.315 J/mol *K, T=310K, F=96,500 J/(V*mol), membrane potential (delta psi) = -60mV (negative inside), Cl- concentration outside cell: 110mM

How is it possible for the GABA activated chloride channel (GABA-A receptor) to switch the direction of ion flow during development? This occurs when the KCC2 transporter becomes active and transports chloride ions out of the cell to lower the chloride concentration inside the cell from 25mM to 4mM. Explain your answer using thermodynamic principles of ion flow through ion channels (passive diffusion while the channel is open). Hint: calculate deltaG (free energy change), R=8.315 J/mol K, T=310K, F=96,500 J/(Vmol), membrane potential (delta psi) = -60mV (negative inside), Cl- concentration outside cell: 110mM

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter11: Genome Alterations: Mutation And Epigenetics

Section: Chapter Questions

Problem 20QP: The cystic fibrosis gene encodes a chloride channel protein necessary for normal cellular functions....

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