Identify the compounds in Figure 7 that are an anhydride, amide, acyl chloride, and ester. Ph Ph Ph CI Ph `N Ph G H. Figure 7 Place the Figure 7 compounds in order based on their relative reactivities in a nucleophilic addition reaction. Considering the approximate pKa values for the conjugate acids of the potential leaving groups, explain the relative reactivities of the compounds in Figure 7.
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- Using the pKa values of the conjugate acids of the leaving groups (the pKa of HBr is -9, and the pKa of H2O is 15.7), explain the difference in reactivity between CH3Br and CH3OH in a nucleophilic substitution reaction.(a) How many Stereoisomers are possible for 9,10- dibromoexadecanoic acid?(b) Addition of bromine to palmitoleic acid primarily yields a set of enantiomers, (±) -three-9,10-dibromohexadecanoic acid. The addition of bromine is an anti-addition to the double bond (ie, it appears to occur through the intermediary of the bromonium ion). Taking into account the stereochemistry of the cis double bond of palmitoleic acid and the stereochemistry of adding bromine,Write a three-dimensional structure for (±) -three-9,10-dibromohexadecanoic acid!A difficult problem in the synthesis of PGF2α is the introduction of the OH group at C15 in the desired conguration.a. Label this stereogenic center as R or S.b. A well known synthesis of PGF2α involves reaction of A with Zn(BH4)2, a metal hydride reagent similar in reactivity to NaBH4, to form two isomeric products, B and C. Draw their structures and indicate their stereochemical relationship.c. Suggest a reagent to convert A to the single stereoisomer X.
- Predict the structure of the product formed in the reaction of the organic base pyridine with the organic acid acetic acid, and use curved arroes to indicate the direction of electron flow.please provide the machanisms of 1a, 1e, 1fArrange the structure on the image with regard to the reactivity towards nucleophilic acyl substitution 1 being the least and 3 being the most
- Is the reaction stereoselective? Does the reaction of bromine with trans-cinnamic acid involve syn-addition, anti-addition, or both? Explain your reasoning.1. how many stereoisomers are possible for 9,10- dibromo hexadecanoic acid? 2. Addition of bromine to palmitoleic acid primarily yields a set of enantiomers, (±) -three-9,10-dibromo hexadecanoic acid. The addition of bromine is an anti-addition to the double bond (ie, it appears to occur through the intermediary of the bromonium ion). Taking into account the stereochemistry of the cis double bond of palmitoleic acid and the stereochemistry of adding bromine, Write a three-dimensional structure for (±) -three-9,10-dibromo hexadecanoic acid!We are currently working with diastereomeric products of acid-base reactions in my organic chemistry class and while I understand the basics of the creation of selectively soluble salt products, drawing the reactions has always been difficult. Our prelab asks us to "draw the expected diasteromeric products from the reaction of racemic phenylsuccinic acid with excess (s)-methylbenzylamine and label the chiral centers" I would really appreciate some help with this!
- Give steucture of organic and inorganic products of the following sn2 reaction, and identify the nucleophile, substrate, and leaving group.When the nitrogen-containing aromatic heterocyclic compounds 1 and 2 are treated with HCl, only 1 forms the hydrochloride salt, whereas compound 2 is unreactive. Provide an explanation for this observed reactivity.What is the predominant form of cyclohexylamine at pH 9.5? Approximately what fraction is in this form?