5'-TTATTTGAGGAGAATGATGTAAACCTGACCCAC-3’ wild-type allele 3'-ААТАААСТССТСТТАСТАСАТТTGGAСTGGGTG-5' 5'-TTATTTGAGGAGAATATGTAAACCTGACCCACG-3’ allele B 3'-ААТАААСТССТСТТАТАСАTTTGGACTGGGTGG-5' • (a) What type of mutation is allele B: insertion, deletion, substitution, or inversion? The type of mutation for allele B was inversion.(ATG from GAT). (b) What effect does the mutation have on the transcribed mRNA? The mutation created a start codon, AUG, which allowed the mRNA to be transcribed. (c) What effect does the mutation have on the translated amino acid sequence? There is no change in the amino acid sequence, there is still a premature stop codon.

5'-TTATTTGAGGAGAATGATGTAAACCTGACCCAC-3’ wild-type allele 3'-ААТАААСТССТСТТАСТАСАТТTGGAСTGGGTG-5' 5'-TTATTTGAGGAGAATATGTAAACCTGACCCACG-3’ allele B 3'-ААТАААСТССТСТТАТАСАTTTGGACTGGGTGG-5' • (a) What type of mutation is allele B: insertion, deletion, substitution, or inversion? The type of mutation for allele B was inversion.(ATG from GAT). (b) What effect does the mutation have on the transcribed mRNA? The mutation created a start codon, AUG, which allowed the mRNA to be transcribed. (c) What effect does the mutation have on the translated amino acid sequence? There is no change in the amino acid sequence, there is still a premature stop codon.

Basic Clinical Laboratory Techniques 6E

6th Edition

ISBN:9781133893943

Author:ESTRIDGE

Publisher:ESTRIDGE

Chapter1: The Clinical Laboratory

Section1.9: Quality Assessment

Problem 3CS

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