In humans, the final product of purine degradation from DNA is uric acid, pKa = 5.61, which is excreted in the urine. What is the percent dissociation of uric acid in urine at a typical pH = 6.0? Why do you think uric acid is acidic even though it does not have a CO;H group? N-H NIH

Q: Dicarboxylic acids have two pKa's. For maleic acid (cis-2-butenedioic acid) these are pka¹ = 2.0,…

A: This can be explaine on the basis of the geometric representation of maleic acid and fumaric acid.

Q: calculate the % yield of preparation of 2-aminobenzoic acid: mass of phthaliamide = 2.95g mass of…

A: In the  question two mass of 2-aminobenzoic acid is given. Hence, the individual percent yield is…

Q: A typical amino acid with one amino group and one carboxylic acid group, such as serine can exist in…

A: At lower pH that means in acidic conditions the carboxylate ion takes up proton and exists as…

Q: a If an acid, HA, dissolves in water such that the Ka is 10000, what is the pK, of that acid? pK, =…

A: Given that: The acid HA dissolves in water  such as: HA (aq) + H2O (l) → H3O+ (aq) + A- (aq) For,…

Q: The y-carboxyl group of Glu has a pK.-value of 4.2; a-COOH = 2.2; a-NH, = 9.7 Calculate the…

A: Glutamic acid is an acidic amino acid. It has three ionizable groups i.e. gamma carboxyl, C-terminal…

Q: (a) The two most acidic hydrogens of uracil have pKa’s of 9.5 and 14.2, respectively. Match these…

A: The acid dissociation constant (Ka) is the measure of the acidity of a substance. pKa is defined as…

Q: How does the pKe of the conjugate acid of benzylamine (CgH5CH,NH2) compare to the pk,'s of the…

A: pKa is inversely proportional to acidity strength. A more acidic molecule will have lower pKa value.…

Q: What is the pKa of Sylvianic Acid if it is 2.3% dissociated at pH = 10.26?

A:

Q: How would the pKa values of carboxylicacids, alcohols, ammonium ions 1RNH32 + , phenol, and an…

A: The strength of a chemical substance acidity is determined by its pKa value.

Q: Phenylalanine is a diprotic acid with pKg = 2.20 for the carboxylic acid group and pK, = 9.31 for…

A: pKa for carboxylic acid group = 2.2 pKa for ammonium group = 9.31

Q: Drug A is a weak acid that has a pKa value of 4. For the Drug A dissolved in Buffer B, calculate…

A: pH is simply a measure of the concentration in a given solution . pKa is defined as the  pH were a…

Q: 13- If you were to have a mythical AA based on Aspartic acid in which the carboxylate on the side…

A: Amino acids are the molecules that contain amino and carboxylic acid group. When both these groups…

Q: 4b) Canavanine is closely related to arginine, and like arginine its side group has a +1 charge when…

A: Canavanine has a similar structure of Arginine.  Hence Canavanine has 3 groups that can be…

Q: Which structure best represents the protonation state of the amino acid cycteine at a pH-value of 7?…

A: option C is correct because at ph 7 which is neutral ph, the amino acid will present in zwitter…

Q: 8. The following proteins represent a wide range of molecular weights and isoelectric points. Mr is…

A:

Q: Biotin has a single ionizable group with a pKa of 4.5. If you dissolved biotin in an aqueous…

A: The question is based on the concept of biomolecules. We have to account for the dissociation…

Q: Consider an amino acid with the following pKa values: pKa1 = 2.71 and pK, = 9.31 At what pH value in…

A: Amino acids are amphoteric in nature due to the presence their ionizable α-amino and α-carboxylic…

Q: 2. What are the pKa's of HCN (hydrocyanic acid), and HF (hydrofluoric acid)? Based only on those pka…

A: We have to write the pka's of HCN (hydrocyanic acid), and HF (hydrofluoric acid). Based only on…

Q: 6. Carbonic acid (H2CO3) has two ionizable protons, with pKa around 6.1 and 10.2. (a) Which species…

A:

Q: Complete and equalize the reactions. Hg22+   +   Cl-   → Pb2+ +      CrO42-  → Bi3+   +    S2-…

A: Please find the attached images for the answer

Q: Please provide the following for each reaction given below; a. The mechanism for the reaction b.…

A: Note :- Since you have posted a question with multiple sub-parts, we will solve first three sub-…

Q: Would HEPES or Tris be a better buff er at pH 7.5?

A: Interpretation- To tell about that which buffer ( HEPES or Tris ) is better at pH =7.5

Q: The structure of the molecule below shows its structure where all of the ionizable/protonatable…

A: The -COOH and -NH3+ group of a peptide is deprotonated at pH greater than the pKa value. The…

Q: Nicotine (structure shown below) has pKa values of 3.2 and 8.1. Account for these values. In your…

A: According to the acid-base theory put forward by physical chemist Gilbert N. Lewis the chemical…

Q: The side chain of acetyl-L-lysine-OMe has a pKa=10.5 and its acid-dissociation reaction  is shown…

A:

Q: Draw the structure of the most abundant form of cysteine in solutions whose pH values are 1, 4, 6,…

A: The molecules found inside human body which have carboxylic and amine group containing monomer units…

Q: On the axes below, sketch the graphs which show the result of adding: 0.1M NaOH to 25cm3 of 0.1M…

A: Interpretation-  To sketch the graph which shows the the result of adding -  0.1M NaOH to 25cm3 of…

Q: The side chain of acetyl-L-lysine-OMe has a pKa=10.5 and its acid-dissociation reaction  is shown…

A:

Q: The Kb for dimethylamine, CH3NH2, at 25oC is 4.0×10-4. What’s the Ka of its conjugate acid?

A:

Q: Draw the structure of the most abundant form of histidine in solutions whose pH values are 1, 3, 5,…

A: Histidine falls under the category of essential amino acid; it is mandatory to incorporate this…

Q: If the pKa values for the bases were given, I would know how to solve this but how can I know just…

A: The proton of the given alkyne is acidic. To deprotonate the alkyne proton the strong base is…

Q: 3) When discovered, Miescher found that the nuclei of pus cells were acidic. We now know that the…

A: DNA is formed of a double helix strands, where each strand is composed of sugar moieties and…

Q: The pka of ascorbic acid is 4.2 at 24C. At what pH is the ratio of the deprotonated form to the…

A: Henderson Hasselbach equation is pH=pKa+log[deprotonated form][protonated form]

Q: The activity of an enzyme requires a glutamic acid to display its -COOH functional group in the…

A: pH of an acid is the negative logarithm of the hydrogen ion concentration present in its aqueous…

Q: Which of the compounds have the lowest pKA, why?

A: We have to predict compound with lowest pKa.

Q: v 12.75a Of the following, which represents a logical retrosynthesis for target molecule A? MgBr OH…

A:

Q: Given a solution of 0.0025 M HC2H3O2, Ka = 1.8 x 10^-5 a. Calculate the pH of the solution. b.…

A: The question is based on the concept of equilibrium. we have to calculate the pH of the acetic acid…

Q: / to loml of 0.01M A9NO3 was added lond afo-o2 M Naz Soy - Show by calculet whether or not…

A: To know whether the product will precipitate or not, the value of reaction quotient (Q) should be…

Q: For an acid HA with a pKa of 5.2, what is the ratio of the concentration of the conjugate base to…

A: The dissociation reaction of acid HA can be written as  => HA ------> H+ + A-  Conjugate base…

Q: Match the following structures to the appropriate pKa value. А. F,CHCOOH B. CI3CCOOH C. CH3COOH D.…

A:

Q: Most of the pKa values given in this text were determined in water. How would the pKa values of…

A: The solubility and dissociation of compound depend upon the type of solvent used for dissolution for…

Q: Lysine (K) is a triprotic amino acid whose most protonated form has a charge of 2+. Its acid…

A: Groups, whose pKa< given pH get deprotonated and groups, whose pKa> given pH get protonated…

Q: In the following reaction, the purpose of amino acid E193 is to: Ad 204 Sta Diminish the metal ion…

A: The organic compound that is composed of amino group and carboxylic group along with an organic…

Q: (a) Glycine is present predominantly as the species TV, PH- 4.6 H,N-CH-COOH. (b) Half of the amino…

A: Fully protonated glycine has two dissociable protons, one on its α-carboxyl group (-COOH) and the…

Q: 7. Explain why 2-phenylethyl boronic acid (Compound A) is an inhibitor of chymotrypsin, which is an…

A: A molecule that binds to an enzyme and reduces its activity is known as an enzyme inhibitor. Through…

Q: The monoanion of adenosine monophosphate (AMP) is an intermediate in phosphate metabolism: А—О—р—он…

A: It is given that pKa of the AMP-OH- anion is 7.21 and the ratio of the anion with its conjugate base…

Q: (b)Given the K, and pK values of the following compounds: Hydrobromic acid (HBr), K= 1.0 x 10;…

A: Solution: We have general knowledge about pH , pKa.  From the pKa we can know about the acidic…