The activity of an enzyme requires a glutamic acid to display its -COOHfunctional group in the protonated state. Suppose the pK, of the -COOHgroup is 4.07.(a) Will the enzyme be more active at pH 3.5 or 4.5? Explain.(b) What fraction of the enzymes will be active at pH = 4.07? Explain.(c) At what pH will the enzyme show 78% of maximal activity?

pH of an acid is the negative logarithm of the hydrogen ion concentration present in its aqueous…

Answered: The activity of an enzyme requires a…

Chemistry for Today: General, Organic, and Biochemistry

9th Edition

ISBN:9781305960060

Author:Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen

Publisher:Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen

Chapter20: Enzymes

Section: Chapter Questions

Problem 20.51E

See similar textbooks

Similar questions

Although the bond energy for the hydrogen bond in a vacuum is estimated to be about 20 kJ/mol, we find that each hydrogen bond in a folded protein contributes much less--probably less that 5 kJ/mol--to the enthalpy of protein stabilization. Suggest an explanation for this difference. Explain briefly.
please explain What percentage of a side-chain sulfhydryl group of cysteine is protonated at pH 7.9?
Review the structure of the standard amino acids and listthose that are capable of acting as acids or bases in enzymecatalysis. Are there any that can function as either acids orbases?
Tyrosine is an amino acid whose side chain has a pKa of 10.1. At pH 7, what protonation form would you expect to find it in?
It is known that the amino acid at position 523 of the cyclooxygenase enzyme is part of the active site. In the isoenzyme COX-1, this amino acid is isoleucine, whereas in COX-2, it is valine. Suggest how such information could be used in the design of drugs that selectively inhibit COX-2.
Bradykinin is a linear nonapeptide released by blood plasma globulin in response to a wasp sting. It is a very potent pain-causing agent. Its constituent amino acids are 2R, G, 2F, 3P, S. The sue of 2,4-dinitrofluorobenzene and carboxypeptidase shows that both terminal residues are arginine. Partial hydrolysis of bradykinin gives the following di- and tripeptides: FS + PGF +PP + SPF + FR + RP
1a) Biotin has a single ionizable group with a pKa of 4.5. If you dissolved biotin in an aqueous solution at pH 7.0, would this ionizable group be protonated or deprotonated? Briefly explain why the molecule would be in that form at pH 7.0.
Which of the following best represents the structure of an amino acid in basic solution (pH=11)?
Calculate the fraction of Asp that has its side chain protonated at pH 7.4
Draw the structure of the peptide ENDQCW. Draw the stereochemistry of the amino acids. Show the ionization state that would be the major form at pH 1. What is the isoelectric point of the peptide?
What happens when the codeine molecule (C18H21NO3) is exposed to air? What reactions are obtained?
Because of its bat configuration, Batman's body produces excess nitrogen and excretes it as a form of urea, NH2CONH2. The reaction that produces it is the combination of arginine (C6H14N4O2) with the body's water to give urea and ornithine (C5H12N2O2), according to the following reaction: C6H14N4OR2 + H2O → NH2CONH2 + C5H12N2OR2 arginine urea ornithine a. Assuming Batman is a perfect (ideal) machine, his body completely removes the produced urea which is 95 mg of urea; calculate the mass of arginine that must have been used by his body. b. Calculate the mass of ornithine that his body produced. c. If the rest of normal humans are not a perfect machine, it has been established that for this case, the normal human produces 0.0003686 lb of ornithine. What is the reaction efficiency of the normal human body compared to Batman's.

SEE MORE QUESTIONS

Recommended textbooks for you

Chemistry for Today: General, Organic, and Bioche…

Chemistry

ISBN:

9781305960060

Author:

Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen

Publisher:

Cengage Learning

Organic Chemistry

Chemistry

ISBN:

9781305580350

Author:

William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:

Cengage Learning

Chemistry for Today: General, Organic, and Bioche…

Chemistry

ISBN:

9781305960060

Author:

Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen

Publisher:

Cengage Learning

Organic Chemistry

Chemistry

ISBN:

9781305580350

Author:

William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:

Cengage Learning

SEE MORE TEXTBOOKS