In order to break the carbon-carbon bond of Acetyl-CoA in a way that does not harm the cell, citrate is produced in the TCA cycle. Explain how switching between 6-carbon, 5-carbon and 4-carbon metabolites eventually allows the two carbons of Acetyl-CoA to be converted to CO2 in a way that does not harm the cell.

In order to break the carbon-carbon bond of Acetyl-CoA in a way that does not harm the cell, citrate is produced in the TCA cycle. Explain how switching between 6-carbon, 5-carbon and 4-carbon metabolites eventually allows the two carbons of Acetyl-CoA to be converted to CO2 in a way that does not harm the cell.

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter19: The Tricarboxylic Acid Cycle

Section: Chapter Questions

Problem 22P: Study Figure 19.18 and decide which of the following statements is false. Pyruvate dehydrogenase is...

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In the first step of the TCA cycle the acetyl group of acetyl-CoA is transferred to oxaloacetate to produce citrate. Where will the carbonyl carbon of that acetyl group be after the first CO2 is expelled? Group of answer choices The first carbon of α-ketoglutarate The last carbon of α-ketoglutarate The fourth carbon of α-ketoglutarate The third carbon of α-ketoglutarate
The citric acid cycle provides for the net synthesis of oxaloacetate from acetyl coa? What is the main role of the tca cycle krebs cycle? What causes the gradient across the thylakoid membrane?
Which of the following statements are TRUE?Multiple answers are accepted for this question a .Two molecules of CO2 are produced each time a molecule of Acetyl-CoA is oxidized. b. During the first turn of the TCA Cycle the carbon atoms of Acetyl-CoA become CO2. c. The number of molecules of ATP that can be produced in the Citric Acid Cycle by substrate level phosphorylation of ADP from two molecules of Acetyl-CoA is 30. d. Fumarate contains a trans double bond. The cis isomer of Fumarate is Maleate which cannot serve as carbon source for a cell. e. Lack of O2 would decrease the rate of the Citric Acid Cycle in red blood cells. f. If a potent inhibitor of Succinyl-CoA Synthetaseis is applied to liver cells both energy production and synthesis of carbohydrate would be affected. g. The overall chemical changes that occur during one complete turn of the Citric Acid Cycle is the complete oxidation of one molecule of Acetyl-CoA plus the production of two molecules of CO2 plus the…
After the formation of pyruvic acid it must be converted into Acetyl CoA to enter the Krebs cycle explain the preparatory steps involved in this process.
Which of the following is true regarding the oxidation of 1 molecule of palmitate to 8 molecules of acetyl CoA by the beta-oxidation pathway? 7 molecules of FADH2 are formed None of the above 8 molecules of FADH2 are formed 8 molecules of NADH are formed BOTH 8 molecules of NADH are formed AND 8 molecules of FADH2 are formed
Acetly CoA can quickly enter the citric acid cyle by joining with a C4 compound and forming citrate. Meanwhile, GTP (or ATP) is generated using inorganic phosphate while succinyl CoA is converted to succinate. What is the main reason both acetly CoA and succinyl CoA can perform such work? a. Acetyl CoA and succinyl CoA both contain coenzyme A, which is a high-energy compound. b. Acetyl CoA and succinyl CoA both form an unstable thioester bond with coenzyme A. c. Acetyl CoA and succinyl CoA both bind with inorganic phosphate which is used to generate ATP (or GTP). d. Acetyl CoA and succinyl CoA both transiently form a covalent bond with the enzymes that catalyze the next reaction, pyruvate dehydrogenase and succinyl-CoA synthetase, respectively. e. Acetyl CoA and succinyl CoA use the energy collected from the electron transport chain.
To begin the TCA cycle, pyruvate must be converted into acetyl-Coenzyme A (acetyl-CoA) by the enzyme complex of pyruvate dehydrogenase. This complex requires 5 different coenzymes to function properly. What are they?
Each cycle of beta (β)-oxidation produces a. 1 FADH2, 1 NADH, and 2 CO2 molecules b. 1 FADH2, 1 NAD+, and 1 acetyl-CoA. c. 1 FADH2, 1 NADH, and 1 acetyl-CoA d. 1 FAD, 1 NADH, and 1 acetyl-CoA.
Suppose that aconitase did not bind its substrate asymmetrically. What fraction of the carbon atoms introduced in one cycle as acetyl-CoA would be released in the first turn of the cycle? What fraction of the carbon atoms that entered in the first cycle would be released in the second turn?
The reaction of acetyl-CoA and oxaloacetate in the TCA cycle forms a. 5-carbon α-ketoglutarate b. 4-carbon Succinyl-CoA c. 6-carbon citrate d. 6-carbon α-ketoglutarate e. 4-carbon citrate
Consider an acetyl CoA that enters the TCA cycle. Let’s call this cycle “Cycle 1.” Let’s say you put a radiolabel on the carbonyl carbon of acetyl CoA that will allow us to track this carbon through the TCA cycle. Now, trace its path through the TCA cycle and answer the following questions: (a) Does the carbonyl carbon of Acetyl CoA come out as CO2 in Cycle 1? (b) If your answer to (a) was No, in which cycle does it come out as CO2 (Cycle 2, 3, 4 …)
In the liver, what is the fate of pyruvate under conditions of the Cori Cycle? Acetyl CoA to fuel TCA Conversion to oxaloacetate primarily for glucose biosynthesis Conversion to lactate Conversion to oxaloacetate primarily for amino acid biosynthesis