Angiotensin Converting Enzyme (ACE) is the target of ACE inhibitors such as captopril that are used therapeutically to control blood pressure. The enzyme ACE converts angiotensin I to angiotensin II. Angiotensin II is an octapeptide with the sequence Asp-Arg-Val-Tyr-Ile-His-Pro-Phe. What will its net charge be at pH 7? OA) -2 B) -1
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- You are given two proteins with a pI of 4.5 and pI of 7.7. In an example of an anion-exchange column, can you use a buffer to separate these two proteins? What buffer protein can be used to separate the two proteins mentioned above?The greatest buffering capacity at physiological pH would be provided by a protein rich in which of the following amino acids? Choose one from among the possible answers and explain. Serine Cysteine Alanine HistidineA mixture of amino acid lysine, alanine, aspartic acid is subjected to an anionic exchanger Dowex-1-Cl what would be the order of it elutin?
- Consider the decapeptide angiotensin I. Treatment of angiotensin I with ACE (the angiotensin-convertingenzyme) cleaves only the amide bond with the carbonyl group derivedfrom phenylalanine to afford two products. The larger polypeptide isangiotensin II, a hormone that narrows blood vessels and increasesblood pressure. Give the amino acid sequence of angiotensin II usingthree-letter abbreviations. ACE inhibitors are drugs that lower bloodpressure by inhibiting the ACE enzymeIn a 0.1000 M acetic acid solution at 25 degrees celsius , the acid ionizes to the extent of about 1.34 %. Since each molecule of acetic acid which ionizes produces 1 H+ ion and 1 C2H3O2- ion, the concentration in the solution are: HC2H3O2 < -----------> H+ + C2H3O2-A patient comes into your office complaining of Covid-19 symptoms. As part of the routine work-up, you take a blood profile and realize that their blood pH is 7.55. Which of the following is true?
- Write the one letter code for the oligopeptide Ser-Cys-Ile-Glu-Asn-Cys-Glu and calculate the total charge on it at pH 4.5.What is the pH of a glycine solution in which the alpha-carboxyl group is one third dissociated? Given pka1=2.3, pka2=9.6Tomato juice has a OH- concentration equal to 1 X 10 -10, what is the pH of this solution?
- If you added three proteins (Protein A, pI 5.0; Protein B, pI 6.0; Protein C, pI 7.0) to an anion exchange column equilibrated with bicine buffer, pH 8.5, in what order would these protein be expected to elute as the column was loaded, washed, and then increasing amounts of NaCl were added?What are the molarity and the normality of a solution made by dissolving 25 g of citric acid (triprotic, C6H5O7H3) in enough water to make 800 mL of solution?The molecular formula for glucose is C6H12O6. What would be the molecular formula for a polymer made by linking ten glucose molecules together by dehydration reactions? Group of answer choices A. C60H120O60 B. C60H102O51 C. C60H100O50 D. C60H111O51 Use the following information to answer the following questions."The native structure of hemoglobin (HB) comprises of two α and two β subunits, each of which carries a heme group. There appear to be no previous studies that report the in-vitro folding and assembly of Hb from highly unfolded α and β globin in a 'one-pot' reaction. One difficulty that has to be overcome for studies of this kind is the tendency of Hb to aggregate during refolding. This work demonstrates that denaturation of Hb in 40% acetonitrile at pH 10.0 is reversible." (J Am Soc Mass Spectrum 2007, 18, 8-16)In sickle-cell disease, as a result of a single amino acid change, the mutant hemoglobin tetramers associate with each other and assemble into large fibers.…