Phosphonacetyl-L-aspartate (PALA) is a potent inhibitor of aspartate transcarbamoylase because it mimics the two physiological substrates of the enzyme. However, in the presence of substrates, low concentrations of PALA increase the reaction rate of aspartate transcarbamoylase. Explain this result.

Phosphonacetyl-L-aspartate (PALA) is a potent inhibitor of aspartate transcarbamoylase because it mimics the two physiological substrates of the enzyme. However, in the presence of substrates, low concentrations of PALA increase the reaction rate of aspartate transcarbamoylase. Explain this result.

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter23: Fatty Acid Catabolism

Section: Chapter Questions

Problem 21P: Using the ActiveModel for enoyl-CoA dehydratase, give an example of a case in which conserved...

See similar textbooks

Related questions

Q: Imagine you are going to label a gene associated with apoptosis in Symbiodiniaceae with a Yellow…

A: Exons are coding sequences and introns are the non-coding sequences. Splicing is the process of…

Q: CONNECT Explain why the proton gradient formed du chemiosmosis represents a state of low entropy.…

A: Oxidation of glucose into pyruvate followed by oxidation of pyruvate into acetyl CoA and then…

Q: C. TBARS Assay 1. In a test tube, mix 1 mL of the samples and 1 mL of thiobarbituric acid reagent.…

A: Sources of error can be defined as the factors which affect the accuracy and precision of an assay.…

Q: Provide 5 differences of HDL and LDL and explain each biochemically.

A: "Lipoproteins," a class of proteins, carry cholesterol through into the blood. Two different…

Q: At pH 5, what is the net charge of the pentapeptide Val-Glu-Cys-Ser-Lys? O-1 O 0 O +1 O +2

A: The amino acids contain ionizable groups. The ionic form of theses ionizable groups depends on the…

Q: After you collect the reaction data, at time O the positive control absorbance is 0.92 and after 24…

A: A spectrophotometer can measure the amount of light absorbed by a biomolecule and we can use that…

Q: (a) In tobacco-associated chronic obstructive pulmonary disease (COPD), is the ability of the body…

A: Chronic obstructive pulmonary disease (COPD) is a major lung disorder related to tobacco smoking.…

Q: 4. You are to choose the members of an expedition that will climb several high mountains. Each…

A: Note: Hi! Thank you for the question. We are authorized to answer one question at a time. Since you…

Q: 5. Let's revisit the question from last week's problem set with the cellulase enzyme discovered by…

A: Parameters such as Km and Vmax are used for comparing enzyme activities. If we know the initial rate…

Q: Proteins destined for the peroxisomes can be translocated in their functional shape. True False

A: Protein targeting is a biological process by which the cells localize the proteins in different…

Q: What amino acid(s) is(are) deemed to be present when a positive reaction is obtained upon heating in…

A: The lead acetate test is a qualitative test for sulfur-containing amino acids. The degradation of…

Q: A binding curve for the binding of the amino acid tryptophan to the protein called TxtE is shown…

A: The binding of ligand 'L' to a protein 'P' to form Protein-Ligand complex 'PL' is represented…

Q: (a) The pyruvate dehydrogenase complex and the a-ketoglutarate dehydrogenase complex have common…

A: Cellular respiration is a collection of three metabolic pathways that generate ATP by oxidation of…

Q: 1. The structure is a monomeric unit of what polynucleotide: DNA or RNA? 2. What is the bond that…

A: The four types of macromolecules are nucleic acid, protein, lipid and carbohydrate. The nucleic…

Q: H H-C=0 ATP H-C-OH HO-C-H V H-COH HOOH Hexokinase H-C-OHO meras-C-OHO kinase H OH H-C-O-P-O H o- HO…

A: Glycolysis is a metabolic pathway during which glucose molecule splits into pyruvate molecules with…

Q: reaction of glyceraldehyde-3-phosphate to form dihydroxyacetone phosphate

A: Glycolysis is a collection of 10 enzymatically catalysed reactions that sequentially oxidise a…

Q: Which of the following shows the structure of aspartic acid at pH 11? a H₂N. ОН ОН b H₂N ОН с H₂N ОН…

A: Aspartic acid (Asp or D); ionic form is known as aspartate, is an α-amino acid that is used for the…

Q: At a substrate concentration that is much greater than the KM for the reaction, which statement is…

A: The velocity of an enzyme catalyzed reaction is given by: V=Vmax×SKM+SWhere,V= velocity of the…

Q: The following peptides were separated using ion-exchange chromatography based on the use of an anion…

A: Ion exchange chromatography separates fractions based on net charge. There are two types of ion…

Q: Clathrin coat features and activities it participated include Its protein chains, triskelion,…

A: Transport mechanism of macromolecules across the plasma membrane is classified as endocytosis and…

Q: A competitive inhibitor interacts with the free enzyme to form an enzyme•inhibitor complex (E•I).…

A: Enzyme inhibition is a process by which the activity of an enzyme is altered. Inhibitors are…

Q: BIOC 384 What would be the long-term effects if ATCase remained in the inactive T state?

A: ATCase(aspartate transcarbamoylase) is an allosteric enzyme that participates in the pyrimidine…

Q: discuss the excitatory NMDA receptor, the role of the Mg++ ion, and how NMDA activation can produce…

A: Hi! Thank you for the question. We are authorized to answer three subparts at a time, since you have…

Q: Consider the reaction: H H SCOA a. What kind of reaction is being performed here? b. What enzyme…

A: Fatty acid oxidation occurs on the outer mitochondrial membrane. The fatty acids must be activated…

Q: The absorption of ketoconazole has been shown to be impaired in patients with drug-induced…

A: Achlorhydria is a condition in which there is no HCl in the stomach. Stomach HCl plays important…

Q: The heme group is a prosthetic group in: OA) Fetal hemoglobin B) Adult hemoglobin C) Myoglobin D) a…

A: Hemoglobin and myoglobin are globular proteins that have the ability to bind molecular oxygen.…

Q: Which of the following types of bonds are not involved in maintaining the tertiary structure of…

Q: No MIC interpretive standards are given for penicillin G against E. coli. Which ONE of the following…

A: Penicillin G is a beta-lactam antibiotic that is used in the treatment of bacterial infections…

Q: Which of the following would NOT be expected in congenital erythropoletic protoporphyria: A…

A: INTRODUCTION : Congenital erythropoietic protoporphyria - It is a disorder which effects the…

Q: Some characteristics of three proteins are listed in the table below: Protein Molecular Weight (Da)…

A: Gel filtration chromatographic procedure in which the components are separated according to their…

Q: F.28. How will phosphorylation of serine change the pKa of Arg, increase, decrease, or no change

A: Serine is a polar but uncharged residue. Arginine is a basic residue due to the presence of an amine…

Q: 1. What is the possible identity of the amino acid? [ Select] V 2. What is the isoelectric point of…

A: Amino acids are biomolecules that have an amino group, a carboxyl group and a side group that is…

Q: Cyt cb562 will form a tetramer in the presence of Zn+2 or in the absence of Zn+2, it will form a…

A: INTRODUCTION : Cyt cb562 - Cytochrome cb562 is a variant of an Escherichia coli four-helix bundle…

Q: Primer design worksheet T7 Promoter Kpn ...KS primer binding site Eco01091 Dra Il BasH II…

A: Polymerase chain reaction (PCR) is a molecular biology technique that can make multiple copies of a…

Q: 3. 1,3-bisphosphglycerate has a high energy bond that can be used to phosphorylate ADP to make ATP…

A: Delta G or the standard free energy of a reaction indicates the tendency of a reaction to move…

Q: Indicate whether each of the following descriptions concerning the molecule sphingosine is true or…

A: Phospholipids are compound lipids composed of fatty acids, alcohol, phosphate group, and nitrogenous…

Q: 1 2 3 4 5 6 N Sample Lysate Name volume 8 Tilapia Cod Sole Perch Tilapia Cod Sole 2 μl Perch 10 με 2…

A: Protein sample: A non-branching sequence of amino acids joined together by a single peptide bond…

Q: Name the nucleosides or nucleotides. HOCH2 OH HOCH 2 OH -20 POCH2 OH OH N N NH₂ N N NH₂

A: The nucleotides are phosphoric acid esters of nucleosides, with phosphate at position C-5'. A…

Q: Multiple choice correct answer and explain every point 2. The factors that contribute to the…

A: Rate of reaction is speed of any chemical or biochemical reaction at which product is formed or…

Q: IR spectrum spectral analysis of aniline and acetanilide. Please ALSO identify functional group.

A: For analysis of ir spectrum of aniline and acetanilide , we have to know the structure and…

Q: In an experiment to determine the degree of saturation in 0.43 g of an unknown lipid, the following…

A: The fatty acids in triglycerides can have one or more double bonds in the hydrocarbon chain. Fatty…

Q: what experiment can be used to confirm that agglutination was due to the binding of the lectins to…

A: Lectin is the collective name for all sugar-binding proteins. Lectins have one or more than one…

Q: Which of the following are true when enzymes and substrate interact? kı E + S= k! ES- - P k-1 the…

A: Assuming the enzyme follows the first order kinetics, The rate of a formation is given by the…

Q: 3. Explain why the structure of myoglobin makes it function well as an oxygen-storage protein…

A: Note: Hi! Thank you for the question. We are authorized to answer one question at a time. Since you…

Q: You digest the octapeptide Met-Glu-Arg- His-Met-Cys-Phe-Leu with trypsin, chymotrypsin and cyanogen…

A: An octapeptide has 8 amino acid residues Amino acid sequences of peptides are written with…

Q: Identify the biochemical role that each plays within a biochemical transformation:…

A: Coenzymes and cofactors are non protein components that are essential for a protein function. Most…

Q: Which of the choices are types of posttranslational modifications a newly synth choices that apply.…

A: Posttranslational modifications are the amino acid side chain modification in some proteins…

Q: In order for a fatty acid stored in an adipocyte to be oxidized by a muscle cell, which of the…

A: INTRODUCTION : Fatty acid oxidation - The oxidation of the fatty acids which are being stored in…

Q: Which mechanisms are used by miRNAs to regulate expression? O Targeted degradation of mRNAs O…

A: Introduction: MicroRNAs (miRNAs) are non-coding endogenous single-stranded RNAs that play an…

Q: The figure below shows the titration curve for the amino acid aspartic acid. There are five key…

A: Amino acids are the main units of protein. Each amino acid has a central carbon atom called Cα. To…

Question

Phosphonacetyl-L-aspartate (PALA) is a potent inhibitor of aspartate transcarbamoylase because it
mimics the two physiological substrates of the enzyme. However, in the presence of substrates, low
concentrations of PALA increase the reaction rate of aspartate transcarbamoylase. Explain this result.

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

This is a popular solution!

SEE SOLUTION Check out a sample Q&A here

Introduction

VIEW

Explanation

VIEW

Trending now

This is a popular solution!

Step by step

Solved in 2 steps

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.

Similar questions

Using the ActiveModel for enoyl-CoA dehydratase, give an example of a case in which conserved residues in slightly different positions can change the catalytic rate of reaction.
If phenylalanine was not an essential amino acid, would diet therapy (the elimination of phenylalanine from the diet) for PKU work?
The sedimentation value of aspartate transcarbamoylase decreases when the enzyme switches to the R state. On the basis of the allosteric properties of the enzyme, explain why the sedimentation value decreases.
When the identical subunits of chicken liver fatty acid synthase are dissociated in vitro, all of the activities can be detected in the separated subunits except for the β-ketoacyl synthase reaction and the overall synthesis of palmitate. Explain these observations.
In the liver, fructose can be converted into glyceraldehyde 3- phosphate and dihydroxyacetone phosphate without passing through the phosphofructokinase-regulated reaction. Show the reactions that make this conversion possible. Why might ingesting high levels of fructose have deleterious physiological effects?
n a particular enzyme, an alanine residue is located in a cleft where the substrate binds. A mutation that changes this residue to glycine has little effect on activity; however, another mutation, which changes the alanine to a glutamate residue, leads to a complete loss of activity. Provide a brief explanation for these observation
. Pyruvate can be processed under anaerobic conditions to ethanol (in yeast) or to lactate (in mammals), as shown. Explain the primary purpose of these reactions. Describe the major biochemical features of each reaction
Explain the chemical change that occurs in converting kynurenine (a product of tryptophan degradation) to kynurenate, a reaction in which α-ketoglutarate is transformed to glutamate.
Dicyclohexylcarbodiimide (DCCD) is a reagent that reacts with Asp or Glu residues. Explain why the reaction of DCCD with the c subunits of F1F0-ATP ase blocks its ATP-synthesizing activity.
What would be the effect on fatty acid synthesis of a mutation in ATPcitrate lyase that reduces the enzyme’s activity? Explain.
Aspartate transcarbamoylase, which is necessary for CTP production, is an essential enzyme for the human body. In the below graph, which line represents the rate of the reaction catalyzes by Aspartate transcarbamoylase? Explain.
Why might the compound shown below acts as a transition state analog of phosphoenolpyruvate carboxykinase. Explain. A drawing of a normal transition state for this enzyme is needed.