In step 2 of the fatty acid biosynthesis, the acetyl-S-synthase condenses the acetyl group (L2) with a malonyl-ACP (C3) and subsequent decarboxylation to acetoacetyl-ACP (C4). Give the molecule [A] after condensation and before decarboxylation in the reaction below. synthase (A) ACP + CO2 s. HS synthase ACP HO
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![In step 2 of the fatty acid biosynthesis, the acetyl-S-synthase condenses the acetyl group (C2)
with a malonyl-ACP (C3) and subsequent decarboxylation to acetoacetyl-ACP (C4). Give the
molecule [A] after condensation and before decarboxylation in the reaction below.
synthase
(A]
ACP + CO2
+ HS synthase
ACP
HO
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- Figure 27.3 illustrates the response of R (ATP-regenerating) and U (ATP-utilizing) enzymes to energy charge. a. Would hexokinase be an R enzyme or a U enzyme? Would glutamine: PRPP amidotransferase, the second enzyme in purine biosynthesis, be an R enzyme or a U enzyme? b. If energy charge = 0.5: Is the activity of hexokinase high or low? Is ribose-5-P pyrophosphokinase activity high or low? c. If energy charge = 0.95: Is the activity of hexokinase high or low? Is ribose-5-P pyrophosphokinase activity high or low?We have stated that fatty acids cannot yield a net gain in carbohydrates in organisms that lack a glyoxalate pathway. Why can odd-chain fatty acids be thought to break this rule to a small extent?Which of the following enzyme components of fatty acid synthase has/have a thiol group? A. ketoacyl-ACP reductase B. ketoacyl-ACP synthase C. enoyl- ACP reductase D. acyl carrier protein
- For saturated fatty acids, these reactions can continue as you have drawn until all the carbons of the fatty acid have been oxidized to acetyl-CoA. What is problematic about an unsaturated fatty acid, such as C16:cis-9?If the w-carbon atom of a fatty acyl CoA molecule with a C18 chain is labeled with C14, how many rounds of β-oxidation are required to produce a radioactively labeled acetyl CoA? a. four b. five c. six d. seven e. eight f. nineAnabolic reactions like fatty acid synthesis are inherently endergonic and require exergonic driving forces to proceed forward. Which of the following statements correctly describes the thermodynamics at play in the substrate activation step of fatty acid synthesis and the importance of this step in downstream elongation of the fatty acid chain? (A) Acetyl CoA carboxylase (ACC1) provides free energy that powers the carboxylation of acetyl CoA to form malonyl CoA.(B) The formation of malonyl CoA is powered by the exergonic carboxylation of acetyl CoA.(C) The formation of a b-ketoacyl ACP in the first step of fatty acid synthesis is driven forward because b-ketoacyl synthase hydrolyzes ATP. (D) The addition of two carbons to the growing fatty acid chain is powered by malonyl ACP decarboxylation.(E) Decarboxylation of malonyl ACP is exergonic and the free energy that is released is coupled to ATP synthesis.
- We have encountered reactions similar to the oxidation, hydration, and oxidation reactions of fatty acid degradation earlier in our study of biochemistry. What other pathway employs this set of reactions?Which of the following is a true statement regarding sphingolipid synthesis? (A) The first step in sphingolipid synthesis is the condensation of palmitoyl CoA with aspartate to form b-ketosphinganine.(B) This process requires the reduction of a ketone that uses NADH as the reducing agent.(C) A fatty acid is attached to dihydrosphingosine to form dihydroceramide. (D) FAD is using as an oxidizing agent to remove a double bond from dihydroceramide.(E) The formation of sphingomyelin requires the attachment of a glucose or galactose molecule to ceramide.Consider the complete oxidation of a mixed TAG containing the following fatty acid residues:At carbon 1: cerotic acidAt carbon 2: heptadecanoic acidAt carbon 3: palmitoleic acid Draw the structure of the mixed TAG.
- The rate-limiting step in fatty acid synthesis is: a. The reduction of the acetoacetyl group to a ?-hydroxybutyryl group b. Formation of malonyl-CoA from malonate and coenzyme A. c. Condensation of acetyl-CoA and malonyl-CoA. d. The reaction catalyzed by acetyl-CoA carboxylase.All of the following are accurate contrasts for beta oxidation vs fatty acid synthesis except which of the following statements? Group of answer choices The hydroxylacyl group differs in stereochemistry between beta oxidation and biosynthesis CoA is the acyl carrier group in beta oxidation, acyl carrier protein is the carrier in biosynthesis The carbon unit resulting from beta oxidation is acetyl-CoA, the carbon unit for biosynthesis is malonyl-CoA FAD is an electron acceptor in beta oxidation, NADP+ is the electron acceptor in biosynthesisThe following link carbohydrate metabolism with lipid biosynthesis: (a) How many molecules of glucose are required to provide the carbon for synthesis of one molecule of palmitate? (b) How many molecules of glucose are required if all of the glucose first proceeds through the pentose phosphate pathway before proceeding through the rest of glycolysis on its way to pyruvate?