Leigh's disease is a mitochondrially inherited disease with symptoms that include seizures, fatigue, imp problems, and ataxia. The pedigree shows the presence of Leigh's disease in three generations. Individı and one son, and individual 6 had one daughter and two sons. Which of the individuals indicated are affected by Leigh's disease? Place the correct symbols on the pe and unaffected individuals. I 1
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- In pedigrees, individuals are usually specified by using a Roman numeral for their generation in the chart and an Arabic number for their position (reading left to right) within that generation. If we use the letter c for the allele that causes cystic fibrosis, what are the genotypes of individuals III-3 and III-4 (the third and fourth individuals shown in generation III) in the pedigree that shows this disease?From the pedigree in Figure 3-25, what principle can youdeduce about the inheritance of mitochondrial diseasefrom affected fathers?Using the given pedigree chart, suppose individuals III-1 and III-2 are expecting their sixth child. What is the chance (percent) that the sixth child will have the sickle cell trait? 
- Wooly hair is a rare dominant trait found in people of Scandinavian descent in which the hair resembles the wool of a sheep. Amale with wooly hair, who has a mother with straight hair, movesto an island that is inhabited by people who are not of Scandinavian descent. Assuming that no other Scandinavians immigrate tothe island, what is the probability that a great-grandchild of thismale will have wooly hair? (Hint: You may want to draw a pedigree to help you figure this out.) If this wooly-haired male haseight great-grandchildren, what is the probability that one out ofeight will have wooly hair?The given pedigree chart corresponds with generational cystic fibrosis. If individuals III-2 and III-3 were to have a second child, what is the probability that their second child will have cystic fibrosis? Galactosemia is a recessive human disease that istreatable by restricting lactose and glucose in the diet.Susan Smithers and her husband are both heterozygous for the galactosemia gene.a. Susan is pregnant with twins. If she hasfraternal (nonidentical) twins, what is theprobability both of the twins will be girls whohave galactosemia?b. If the twins are identical, what is the probabilitythat both will be girls and have galactosemia?For parts (c–g), assume that none of the children isa twin.c. If Susan and her husband have four children, whatis the probability that none of the four will havegalactosemia?d. If the couple has four children, what is the probability that at least one child will have galactosemia?e. If the couple has four children, what is the probability that the first two will have galactosemia andthe second two will not?f. If the couple has three children, what is the probability that two of the children will have galactosemia and one will not, regardless of order?g. If…
- In Figure 2-19, assume that the pedigree is for mice, inwhich any chosen cross can be made. If you bred IV-1with IV-3, what is the probability that the first baby willshow the recessive phenotype?Which of the pedigrees shown above could be one showing the inheritance of a non-lethal mitochondrial disease?Tay-Sachs disease is a rare human disease in which toxic substances accumulate in nerve cells. The recessive allele responsible for the disease is inherited in a simple Mendelian manner. For unknown reasons, the allele is more common in populations of Ashkenazi Jews of eastern Europe. A woman is planning to marry her first cousin, but the couple discovers that their shared grandfather’s sister died in infancy of Tay-Sachs disease.a. Draw the relevant parts of the pedigree, and show all the genotypes as completely as possible. b. What is the probability that the cousins’ first child will have Tay-Sachs disease, assuming that all people who marry into the family are homozygous normal?
- . Tay-Sachs disease is a rare human disease in which toxic substances accumulate in nerve cells. The recessiveallele responsible for the disease is inherited in a simpleMendelian manner. For unknown reasons, the allele ismore common in populations of Ashkenazi Jews ofeastern Europe. A woman is planning to marry her firstcousin, but the couple discovers that their sharedgrandfather’s sister died in infancy of Tay-Sachsdisease.a. Draw the relevant parts of the pedigree, and showall the genotypes as completely as possible.b. What is the probability that the cousins’ first childwill have Tay-Sachs disease, assuming that all peoplewho marry into the family are homozygous normal?For this pedigree, give the most likely mode of inheritance, assuming that the trait is rare. For the pedigree, what is the probability that III-4 and III-5 will have a boy AND he will be affected?Ann's family has a history of cystic fibrosis, a recessive genetic disease. In the pedigree, family members who are afflicted with the disease are shown in red. Members who are unafflicted may or may not be carriers. Which of the given family members can be identified definitively as unafflicted carriers of cystic fibrosis?