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Social Sciencelonizable groups in Approximate pKa inpeptides/proteinsа-carboxylSide chain carboxylpeptides/proteins3.14.1Imidazole6.0a-amino8.0Thiol8.3E-amino10.8Aromatic hydroxyl10.9guanidino12.5
Given the chart of pKa’s below, calculate the isoelectric point for tyrosine
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lonizable groups in Approximate pKa in peptides/proteins а-carboxyl Side chain carboxyl peptides/proteins 3.1 4.1 Imidazole 6.0 a-amino 8.0 Thiol 8.3 E-amino 10.8 Aromatic hydroxyl 10.9 guanidino 12.5
Expert Answer
Isoelectric point (pI):
The isoelectric point is the pH of an aqueous solution of an amino acid (or peptide) at which the molecules on average have no net charge. In other words, the positively charged groups are exactly balanced by the negatively charged groups.
For simple amino acids such as tyrosine, the pI is an average of the pKa's of the carboxyl (3.1) and ammonium (8.0) groups.
Calculation for Isoel...
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(рк, (а — соон) + pk, (а — NH,)) pl 2 3.18.0 pl 2 pl 5.6
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