Most fatty acids have an even number of carbons and, therefore, are completely metabolized to acetyl-CoA. A fatty acid with an odd number of carbonsis metabolized to acetyl-CoA and one equivalent of propionyl-CoA. The following two reactions convert propionyl-CoA into succinyl-CoA, a citric acidcycle intermediate, so it can be further metabolized. Each of the reactions requires a coenzyme. Identify the coenzyme for each step. From what vitaminsare the coenzymes derived? (Hint: see Chapter 23.) COO− COO−CH2CH2methylmalonyl-CoA succinyl-CoA CH3CH2 SCoA

Most fatty acids have an even number of carbons and, therefore, are completely metabolized to acetyl-CoA. A fatty acid with an odd number of carbonsis metabolized to acetyl-CoA and one equivalent of propionyl-CoA. The following two reactions convert propionyl-CoA into succinyl-CoA, a citric acidcycle intermediate, so it can be further metabolized. Each of the reactions requires a coenzyme. Identify the coenzyme for each step. From what vitaminsare the coenzymes derived? (Hint: see Chapter 23.) COO− COO−CH2CH2methylmalonyl-CoA succinyl-CoA CH3CH2 SCoA

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter19: The Tricarboxylic Acid Cycle

Section: Chapter Questions

Problem 21P: Complete oxidation of a 16-carbon fatty acid can yield 129 molecules of ATP Study Figure 19.2 and...

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Complete oxidation of a 16-carbon fatty acid can yield 129 molecules of ATP Study Figure 19.2 and determine how many ATP molecules would be generated if a 16-carbon fatly acid were metabolized solely by the TCA cycle, in the form of S acetyl-CoA molecules.
Using the ActiveModel for enoyl-CoA dehydratase, give an example of a case in which conserved residues in slightly different positions can change the catalytic rate of reaction.
Acetly CoA can quickly enter the citric acid cyle by joining with a C4 compound and forming citrate. Meanwhile, GTP (or ATP) is generated using inorganic phosphate while succinyl CoA is converted to succinate. What is the main reason both acetly CoA and succinyl CoA can perform such work? a. Acetyl CoA and succinyl CoA both contain coenzyme A, which is a high-energy compound. b. Acetyl CoA and succinyl CoA both form an unstable thioester bond with coenzyme A. c. Acetyl CoA and succinyl CoA both bind with inorganic phosphate which is used to generate ATP (or GTP). d. Acetyl CoA and succinyl CoA both transiently form a covalent bond with the enzymes that catalyze the next reaction, pyruvate dehydrogenase and succinyl-CoA synthetase, respectively. e. Acetyl CoA and succinyl CoA use the energy collected from the electron transport chain.
The same reactions that were seen in the process of converting pyruvate to acetyl-S-CoA, occur in step ____ of the citric acid cycle as ____________ is converted to _________________.
On these following choices, Malonyl CoA synthase, Malonyl CoA synthetase, Acetyl CoA carboxylase and Acetyl CoA decarboxylase, what is the correct answer in fatty acid synthesis?
A fatty acid (a long straight-chain carboxylic acid with an even number of carbons) is metabolized to acetylCoA, which can then enter the citric acid cycle to be further metabolized. A fatty acid with an odd number of carbons is metabolized to acetyl-CoA and one equivalent of propionyl-CoA. Propionyl-CoA cannot enter the citric acid cycle. Two coenzyme-requiring enzymes are needed to convert it to succinyl-CoA, a compound that can enter the citric acid cycle. Write the two enzyme-catalyzed reactions and include the names of the required coenzymes.
Two carbon atoms are fed into the citric acid cycle as acetyl-CoA. In what form are two carbon atoms removed from the cycle?
Which of the following fatty acids will produce propionyl-CoA in its/their last β-oxidation cycle?
When one of the acetyl CoA is processed through the citric acid cycle, how many times does a secondary alcohol group is oxidized to a ketone group?
How many acetyl CoA molecules can be produced during the complete β-oxidation of this fatty acid?
alpha-ketoglutarate dehydrogenase will do which of the following: Select one: a. Pyruvate is decarboxylated to become acetyl-CoA producing NADH and Carbon dioxide b. Succinate is oxidized to become fumarate forming FADH2 c. Succinyl-CoA becomes Succinate and forms one ATP molecule and Coenzyme A-SH d. Oxaloacetate combines with the acetyl from acetyl-CoA to produce Citric acid(citrate) e. Malate is oxidized to become oxaloacetate forming NADH f. Isocitrate and then decarboxylated and oxidized to produce alpha-ketoglutarate, Carbon dioxide and NADH g. Citrate is rearranged to become Isocitrate h. Fumarate is combined with water to become Malate i. alpha-ketoglutarate is oxidized and decarboxylated to produce Succinyl-CoA, Carbon dioxide and NADH
If a fatty acid containing 13 carbons is subjected to Beta oxidation, how many molecules of Acetyl CoA can be produced?