N-acetyl-p-benzoquinone imine (NAPQI) is a toxic metabolite of acetaminophen that can lead to liver damage. The damage results from the addition to liver proteins, which react as a nucleophile with one of the ring carbons. Propose a reasonable mechanism for the following steps that result in the aromatic ring product. HN' Liver Protein H$ Liver Protein OH
N-acetyl-p-benzoquinone imine (NAPQI) is a toxic metabolite of acetaminophen that can lead to liver damage. The damage results from the addition to liver proteins, which react as a nucleophile with one of the ring carbons. Propose a reasonable mechanism for the following steps that result in the aromatic ring product. HN' Liver Protein H$ Liver Protein OH
Chapter24: Amines And Heterocycles
Section24.9: Heterocyclic Amines
Problem 24P
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