н H30* -N: EN х enamine imine

Q: Draw a stepwise mechanism for the following reaction, one step in the synthesis of the…

A: A stepwise mechanism for the following reaction, one step in the synthesis of the…

Q: Which electrophile is most likely to undergo a 1,2-hydride shift during an electrophilic aromatic…

A: In electrophilic aromatic substitution of benzene in presence of AlCl3. First of all the alkyl…

Q: Rank the following esters from most reactive to least reactive in the first slow step of a…

A: First the reactivity order of given compounds from most reactive to least reactive in the first slow…

Q: An α, β-unsaturated carbonyl compound can be prepared by a reaction known as a…

A: The given reaction is represented as follows:

Q: During the metabolism of glucose, glyceraldehyde 3-phosphate is converted to dihydroxyacetone…

A: Keto –enol tautomerizations means the chemical equilibrium between enol form and keto form. Keto…

Q: Although codeine occurs in low concentration in the opium poppy, most of the codeine used in…

A:

Q: What is the role of the acid in an acid catalyzed acyl substitution reaction? Draw a mechanism for a…

A: we are required to show the mechanism when the salicylic acid and acetic anhydride and sulphuric…

Q: As described in Section 9.16, the leukotrienes, important components in the asthmatic response, are…

A: The given reaction is an example of Radical abstraction and Radical addition reactions. Radical has…

Q: Draw the product formed when phenylacetic acid (C6H5CH2COOH) is treated with each reagent. With some…

A: Since your question has multiple sub-parts, we are solving only first three sub-parts for you. If…

Q: a. N,N-Dimethyl formamide (DMF) -> 1 Bromo Butane b. 2-methyl-2-butanol -> 2 methyl 2 butene c.…

A:

Q: 4. Draw the proper products for the following acid/base reaction, with diisopropylamide (1) acting…

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Q: Identify reagents A and B in the following reaction scheme. This synthetic sequence was used to…

A: A Gilman reagent is a diorganocopper (lithium and copper) reagent, expressed as R2CuLi, where R can…

Q: Draw the products that result from each step in the synthesis of m-bromoaniline. HNO3, H2SO4 Br2,…

A: Step 1: The reaction of benzene with a mixture of conc. HNO3 and conc. H2SO4 is Nitration reaction (…

Q: Direct alkylation of D by treatment with one equivalent of LDA and CH3I does not form ibuprofen.…

A:

Q: Draw the product formed when phenylacetic acid (C6H5CH2COOH) istreated with following reagent. With…

A: Given substrate is : phenylacetic acid (C6H5CH2COOH)  Reagent SOCl2 is the chlorinating agent.…

Q: Enamines and imines are tautomers that contain N atoms. Draw a stepwise mechanism for the…

A: The first step of the acid-catalyzed conversion of enamine X to imine Y is shown as,

Q: Identify the lettered compounds in each reaction sequence.Draw the product formed when…

A: Grignard reagent acts as a nucleophile whereas the C of CO is an electrophilic centre.

Q: a. Potassium permanganate reacting with a benzylic C-H bond. b. PCC reacting with an alcohol c. An…

A:

Q: Treatment of ethyl acetoacetate with NaOEt (2 equiv) and BrCH2CH2Br forms compound X. This reaction…

A: Sodium ethoxide (NaOEt) reagent mainly behaves as "nucleophile". It abstracts hydrogen that is…

Q: Draw the product formed when phenylacetonitrile (C6H5CH2CN) is treated with each reagent. a. H3O+ b.…

A: “Since you have posted a question with multiple sub-parts, we will solve first three sub-parts for…

Q: Below is one of the reactions used in the synthesis of lopinavir. What type of reaction is this? H…

A: In the given transformation NaOH is acting as a base and THF is solvent.

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A: The mechanism is as follows,

Q: Tautomerization in base resembles tautomerization in acid, but deprotonation precedes protonation in…

A: Keto-enol tautomers are the isomeric forms which represents the same compound but variation in the…

Q: Rank the following esters in order of decreasing reactivity in the first slow step of a nucleophilic…

A: For the formation of the tetrahedral intermediate, the nucleophilic acyl substitution reaction takes…

Q: What results when dimethylsulfide is treated with methyl iodide? 1) CH,I 2)- NH 3) -H A. B. C. D.

A: The reaction taking place is given as,

Q: Enamines and imines are tautomers that contain N atoms. Draw astepwise mechanism for the…

A: The mechanism of the above reaction is as given below:

Q: Acid-catalyzed dehydration of β-hydroxy carbonyl compounds occurs by the mechanism. With this in…

A: Given reaction is:       Step wise mechanism of the given reaction is :

Q: Identify the lettered compounds in each reaction sequence.Draw the product formed when…

A: Intermediate that formed when C6H5CH2CN is treated with the DIBAL-H is;

Q: Devise a stepwise mechanism for the following reaction. (Hint: The mechanism begins with the…

A: A reaction mechanism is the order of basic steps by which a chemical reaction occurs. A reaction…

Q: Predict the major product formed when hexanoyl chloride is treated with LIAIH4 (excess), followed by…

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Q: 7) Draw the arrow-pushing mechanism for the following reaction. 1) P(OCH,CH,)3, NaH 2)…

A:

Q: Polyethylene terephthalate is also prepared by the transesterification of dimethyl terephthalate…

A: To draw the nucleophilic acyl substitution mechanism for the preparation of PET.

Q: Treatment of ethyl acetoacetate with NaOEt (2 equiv) and BrCH2CH2Br forms compound X. This reaction…

A: The structure of "X" in the formation of illudin-S by acetoacetic ester synthesis is shown below.

Q: Propose an efficient synthetic approach using diethyl malonate as one of the reagents for the…

A: This is an basic organic reaction.  The synthesis can be done in 2-3 steps.

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Q: 41. Draw an arrow pushing mechanism to illustrate the formation of t-butyl bromide from t-butanol…

A: Kindly find the answer attached in handwritten note.

Q: The reaction of S-ethyl thiobenzoate with 2-aminoethanol gives two different products depending on…

A: The first reaction scheme-1 includes that reaction of S-ethyl benzothioate (1) with 2-aminoethanol…

Q: Q 9.34: Which of the following is not an effective base for deprotonating a terminal alkyne? A…

A: (B) Potassium hydroxide. KOH is not an effective base for deprotonating a terminal alkyne because it…

Q: 5. Although codeine occurs in low concentration in the opium poppy, most of the codeine used in…

A: In reaction, reagent KOH is base which abstracts acidic proton whereas alkyl part of alkyl halide…

Q: Draw a possible forward synthesis to form the following compounds using MeOH, ETOH, NaCN and benzene…

A: To synthesize the following molecule , retrosynthetic approach is very essential . After retro…

Q: Draw the products of the following reactions w given starting material 1. HCl 2. KMnO4 3. BH3…

A: We have to find out the product when 1-ethynylcyclohexane react with different reagent.  1) with HCl…

Q: Following are two possible retrosynthetic analyses for the anticholinergic drug cycri- mine. Fill in…

A: Reaction of Piperidine with epoxide ring initiates the ring opening of epoxide and the product on…

Q: Polyethylene terephthalate is also prepared by the transesterication of dimethyl terephthalate with…

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Q: H3CO OCH3 H* catalyst H20

A:

Q: Quinapril (trade name Accupril) is used to treat high blood pressure andcongestive heart failure.…

A: The amine functional group is represented as R-NH2 where R can be an alkyl or aryl group. If the R…

Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.