nheritance of one mutant allele of BRCA1 is associated with 70-80% lifetime risk of developing breast cancer in females. How is this possible? Select all that apply. The loss of the mutant chromosome during mitosis A point mutation in the allele of BRCA1 inherited from the normal parent Repair of the heteroduplex region containing a mismatch between the normal DNA strand and the mutant DNA strand Nondisjunction of the normal chromosome during mitosis A deletion of the gene copy inherited from the affected parent Mitotic recombination in the region between the BRCA1 gene and the centromere of the chromosome
BRCA1 is mutated in a large percentage of hereditary breast and ovarian cancers. BRCA1 protein serves as a key enzyme in repairing DNA double-strand breaks. More than 800 mutations in the BRCA1 are clinically significant. This collection of mutations include missense mutations, small deletions, and large rearrangements that result in a protein with reduced function or no protein product.
Inheritance of one mutant allele of BRCA1 is associated with 70-80% lifetime risk of developing breast cancer in females. How is this possible?
Select all that apply.
A point mutation in the allele of BRCA1 inherited from the normal parent
Mitotic recombination in the region between the BRCA1 gene and the centromere of the chromosome carrying BRCA1
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