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a. If an individual who is homozygous for the mutation found in individual 2 and heterozygous for the mutation found in individual 4 marries an individual who is homozygous for the mutation found in individual 4 and heterozygous for the mutation found in individual 2, what will be the phenotype of their children? b. List the intermediate that would build up in each of the types of children who could not produce protein E.

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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 10, Problem 11QP
Textbook Problem
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  1. a. If an individual who is homozygous for the mutation found in individual 2 and heterozygous for the mutation found in individual 4 marries an individual who is homozygous for the mutation found in individual 4 and heterozygous for the mutation found in individual 2, what will be the phenotype of their children?
  2. b. List the intermediate that would build up in each of the types of children who could not produce protein E.

Summary Introduction

To explain: The possible phenotype of the children born if an individual having homozygosity for mutation present in individual 2 and heterozygosity for mutation found in individual 4 marries an individual who is having homozygosity for mutation that is found in individual 4 and heterozygosity for the mutation found in individual 2.

Introduction: Production of proteins is controlled by the genetic code for that particular protein, present in the genome of that organism. Different metabolic pathways are controlled by different proteins. Synthesis of these metabolic pathway controlling proteins can be interrupted by many different reasons that are present in the pathway. Combination of genes from two different organisms can alter the effect of the genetic code for that protein based on the presence of alleles in homozygocity or heterozygocity

Explanation of Solution

To find the phenotypes of the children born from the given parents, block points in each individual can be determined as done in QP 10. The obtained results were as follows:

In individual 1 and individual 6, the pathway proceeds in a normal manner after addition of compound C on which enzyme 4 acts. Hence the block point in individual 1 and individual 6 is faulty enzyme 3 that do not allows conversion of compound B to C

In individual 2 and individual 7, the pathway proceeds in a normal manner after addition of compound B on which enzyme 3 acts. Hence the block point in individual 2 and individual 7 is faulty enzyme 2 that do not allows conversion of compound A to B.

In individual 3 and individual 8, the pathway proceeds in a normal manner after addition of compound D on which enzyme 5 acts. Hence the block point in individual 3 and individual 8 is faulty enzyme 4 that do not allows conversion of compound C to D.

Individual 4 do not forms protein E even after addition of any of the intermediate compounds. Hence based on the pathway of protein E production, it can be said that in individual 4 has a faulty enzyme 5 that do not converts compound D into protein E.

In individual 5, addition of all the intermediated forms protein E. this shows that all the enzymes working in the pathway, except enzyme 1, are functional. In individual 5, faulty enzyme 1 is not capable of converting compound Z into A which blocks the whole pathway.

Let M denote functioning Enzyme II, and m denote nonfunctional Enzyme II...

Summary Introduction

To determine: The intermediates that will be formed in each of the type of children who could not produce protein E.

Introduction: Production of proteins is controlled by the genetic code for that particular protein, present in the genome of that organism. Different metabolic pathways are controlled by different proteins. Synthesis of these metabolic pathway controlling proteins can be interrupted by many different reasons that are present in the pathway. Combination of genes from two different organisms can alter the effect of the genetic code for that protein based on the presence of alleles in homozygocity or heterozygocity

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