но naproxen

Q: Rank the labeled N atoms in the anticancer drug imatinib (trade name Gleevec) in order of increasing…

A: According to Lewis acid-base theory, the acidic and basic nature of the substance. A Lewis base can…

Q: Which molecule is hydrolyzed most slowly with aqueous NAOH? D. C. В. A.

A:

Q: Avobenzone is a conjugated compound that absorbs ultraviolet light with wavelengths in the 320–400…

A: The structure of Avobenzone is - The retrosynthetic analysis of avobenzone are shown below -

Q: One step in the synthesis of the antihistamine fexofenadine (Section 23.5) involves acid-catalyzed…

A: Given Structure: Reaction of A in presence of acid-calatysed hydration of H+ Following products are…

Q: The analgesic naproxen can be prepared by a stepwise reaction sequence from ester A. Using enolate…

A: The most acidic proton in compound A will be the one which is attached to the carbon adjacent to the…

Q: (a) (c) (b) (d)

A: The questions are based on the concept of organic reactions. we have to identify the reagents which…

Q: Hydroxy aldehydes A and B readily cyclize to form hemiacetals. Draw the stereoisomers formed in this…

A: Hemiacetal is a compound which is generated by the addition of alcohol to the aldehyde. Another…

Q: Which carbonyl groups in the anticancer drug Taxol will undergo nucleophilic addition, and which…

A: The nucleophilic addition is a characteristic reaction of carbonyl compounds. It is sensitive…

Q: Draw a stepwise mechanism for the conversion of lactone C to carboxylic acid  D. C is a key…

A:

Q: Draw a stepwise mechanism for the conversion of lactone C to carboxylic acid D. C is a key…

A: A stepwise mechanism for the conversion of lactone C to carboxylic acid D can be drawn as

Q: Diphenhydramine, the antihistamine in Benadryl, can be prepared by thefollowing two-step sequence.…

A: The structure of diphenhydramine has to be given.

Q: (a) Explain how NaBH4 in CH3OH can reduce hemiacetal A to butane-1,4-diol (HOCH2CH2CH2CH2OH). (b)…

A: The reaction of hemiacetal A will be given by the sodium borohydride in presence of methanol as-

Q: (a) Explain how NaBH4 in CH3OH can reduce hemiacetal A to butane-1,4-diol (HOCH2CH2CH2CH2OH). (b)…

A: (a) The given compound A is a hemiacetal. Sodium borohydride (NaBH4) is a strong reducing agent. It…

Q: Rank the compounds in each group in order of increasing reactivity toward nucleophilic attack.

A: a) Aldehydes are more reactive than ketones towards Nucleophilic attack. This is because, due to…

Q: One step in the synthesis of the antihistamine fexofenadine involves acid-catalyzed hydration of the…

A: Acid catalyzed hydration of alkynes- Acid catalyzed hydration of alkynes produce ketone.…

Q: What product is formed when each compound is treated with either LiAlH4 (followed by H2O), or NaBH4…

A:

Q: Draw a stepwise mechanism for the following reaction and explain the stereochemistry of the product.

A: The protonation step is shown below.

Q: What neutral nucleophile is needed to convert dihalide A to ticlopidine, an antiplatelet drug used…

A: The structure of ticlopidine is different from the structure of dihalide A. One of the chlorine…

Q: What acetylide anion and epoxide are needed to synthesize each compound?

A: (a) From the retro synthesis, Acetylide anion and epoxide are needed to synthesize the given…

Q: Mol of 5-hydroxypentanoic acid reacts with 1 mol of SOCI2 and then with 1 mol of dimethylamine. What…

A: In a chemical reaction, two or more compounds react with each other to form product(s). Organic…

Q: 5.45 Use resonance structures of the possible carbocation intermediates to explain why bromination…

A:

Q: Rank the following sets of compounds by the indicated criteria. A) Rate of reaction with Br/FeBrs…

A: Rate of the electrophilic aromatic substitution reaction  depend upon electron  density  on the…

Q: Attenol A and pinnatoxin A are natural products isolated from marine sources. (a) Locate the…

A: The diether derivates of the aldehydes and ketones are known as acetals or ketals. The imine is a…

Q: Treatment of ketone A with LDA followed by CH3CH2I did not form the desired alkylation product B.…

A: The product formed in the reaction is shown below.

Q: Draw the product formed when phenylacetic acid (C6H5CH2COOH) istreated with following reagent. With…

A: Phenyl acetic acid contain a phenyl group and a carboxylic acid functional group. It is a white…

Q: What compound undergoes metathesis to form each of the following compounds?

A: First break the double bond present in product made after metathesis reaction and add =CH2 to each…

Q: What is the major enolate (or carbanion) formed when each compound is treated with LDA?

A: The major product of enolate (carbanion) formed when the compound is treated with LDA is given…

Q: What starting materials are needed to prepare each compound by the Michael reaction?

A: The reaction in which an enolate ion of one carbonyl compound undergoes conjugate addition reaction…

Q: What neutral nucleophile is needed to convert dihalide A to ticlopidine, an antiplatelet drug used…

A: The ticlopidine is framed by supplanting one of the Cl with a nucleophile.  Also, the nucleophile…

Q: Synthesize each compound from cyclohexanone and organic halides having ≤ 4 C's. You may use any…

A: (a) Treatment of cyclohexanone with a strong base, LDA, followed by the reaction with methyl bromide…

Q: CI I II IV

A: The correct answer is given below

Q: Draw the products formed when A or B is treated with fo following agent. In some cases, no reaction…

A:

Q: 2. Draw the most stable enol tautomer for the following compounds b. C.

A: Ketones form keto - enol tautomers , which contain alkene functional group ( C=C ) and Alcoholic…

Q: Devise a synthesis of compound A from the given starting materials. You may use any other inorganic…

A:

Q: Even though B contains three ester groups, a single Dieckmann product results when B is treated with…

A: To find: The structure of the product and explanation

Q: Even though B contains three ester groups, a single Dieckmann product results when B is treated with…

A: Given compound:

Q: Rank the following compounds in order of increasing reactivity in nucleophilic addition.

A: Given compounds,

Q: Draw the product formed when phenylacetic acid (C6H5CH2COOH) istreated with following reagent. With…

A: SOCl2 reagent is used to convert acid into halide. This is one of the preferred pathway because the…

Q: β-Vetivone is isolated from vetiver, a perennial grass that yields a variety of compounds used in…

A: a.

Q: The pKa of p-cyclopropylbenzoic acid is 4.45 . Is cyclopropylbenzene likely to be more reactive or…

A:

Q: The analgesic naproxen can be prepared by a stepwise reaction sequence from ester A. Using enolate…

A: To find: The reagents which are required to convert compound A to naproxen. Structure of the each…

Q: [8] Which compound when treated with acid and or heat would yield following ČH3

A: Given Reactant Reaction Condition Treated with acid or Heat Product To be determined

Q: Arrange in decreasing order according to their reactivity towards an electrophile. H A В

A:

Q: Which of the following reacts fastest in nucleophilic addition reaction? a. Acetic acid O b. Ethanol…

A:

Q: What neutral nucleophile is needed to convert dihalide A to ticlopidine, an antiplatelet drug used…

A: The characteristic reaction of alkyl halide is nucleophilic substitution reaction. The substitution…

Q: Br from phenol a. b. from benzene CI

A:

Q: Purine is a heterocyclic compound with four nitrogen atoms. a. Which nitrogen is most apt to be…

A: (a) In purine compound, four nitrogen atoms are present and all are sp hybridized nitrogen atoms.…

Q: (c) Arrange the following compounds in order of increasing acidity, and explain the reasons fo your…

A:

Q: Draw the product formed when phenylacetic acid (C6H5CH2COOH) istreated with following reagent. With…

A: Given reaction,  Phenylacetic acid (C6H5CH2COOH) with NH3 (1 equiv)

Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.