Pleas solve ASAP Problem 1A. Aspartate has 3 pka values referring to its 3 readily (de)protonatable functional groups: 1.9, 3.6,and 9.6. Each pka refers to the conjugate acid form of the functional group. Draw aspartate inthis form, where each of the 3 functional groups is in its conjugate acid protonation state,labeling each functional group with the relevant pka.B. Briefly explain the rationale for your assignment of pka values above (max 2 sentences).C. Now draw aspartate in its most common protonation state at pH 7.6 (a common intracellular pHvalue).D. Redraw aspartate at its 2nd most common protonation state at pH 7.6.E. What is the approximate fraction of aspartate in each of these 2 protonation state at pH 7.6?F. To activate aspartate to react on its side chain, one option is to make the side chain into an acidchloride. Draw that analog.G. Draw the reaction of this analogue with diaminoethane (H2N-CH2-CH2-NH2), using the arrowformalism, clearly showing the major reaction intermediate.H. Mammalian metabolism does not involve acid chlorides. Draw two variants of aspartate thatwould be similarly activated to react (at the same position) with diaminoethane to produce thesame nitrogen-containing product, but relying instead on functional groups found in centralcarbon metabolism.1. The nitrogen-containing product of these reactions can undergo an intramolecular reaction toform a new C-N bond. Draw this reaction using the arrow formalism.J. Why is this reaction preferred over alternative intermolecular reaction(s) that could form thesame functional group? (max one sentence)

Problem 1 A. Aspartate has 3 pka values referring to its 3 readily (de)protonatable functional groups: 1.9, 3.6, and 9.6. Each pKa refers to the conjugate acid form of the functional group. Draw aspartate in this form, where each of the 3 functional groups is in its conjugate acid protonation state, labeling each functional group with the relevant pka. B. Briefly explain the rationale for your assignment of pka values above (max 2 sentences). C. Now draw aspartate in its most common protonation state at pH 7.6 (a common intracellular pH value).

Problem 1 A. Aspartate has 3 pka values referring to its 3 readily (de)protonatable functional groups: 1.9, 3.6, and 9.6. Each pKa refers to the conjugate acid form of the functional group. Draw aspartate in this form, where each of the 3 functional groups is in its conjugate acid protonation state, labeling each functional group with the relevant pka. B. Briefly explain the rationale for your assignment of pka values above (max 2 sentences). C. Now draw aspartate in its most common protonation state at pH 7.6 (a common intracellular pH value).

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter27: Amines

Section: Chapter Questions

Problem 5E

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