The genome of Drosophila melanogaster, a fruit fly, was sequenced in 2000. However, this “completed” sequence did not include most heterochromatin regions. The heterochromatin was not sequenced until 2007 (R. A. Hoskins et al. 2007. Science 316:1625–1628). Most completed genome sequences do not include heterochromatin. Why is heterochromatin usually not sequenced in genome-sequencing projects?
The genome of Drosophila melanogaster, a fruit fly, was sequenced in
2000. However, this “completed” sequence did not include most
heterochromatin regions. The heterochromatin was not sequenced until
2007 (R. A. Hoskins et al. 2007. Science 316:1625–1628). Most
completed genome sequences do not include heterochromatin. Why is
heterochromatin usually not sequenced in genome-sequencing projects?
Answer:
Introduction:
The Drosophila melanogaster heterochromatin sequence by the Drosophila Heterochromatin Genome Project (DHGP) studies shows the gene mapping, molecular organization, and genes function present in pericentromeric heterochromatin.
Steps involved in genome sequencing of Drosophila melanogaster:
1) Finding a DNA clone to sequence.
2) Later Sequencing is done on the DNA clone.
3) Accumulating sequence data from multiple clones to regulate overlap and create a contiguous sequence.
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