The goal of most gene therapies is to insert a healthy copy of a gene into the genome.  Besides CRISPR, techniques for integrating DNA into the genome do not target that DNA to a particular genomic location and thus different cells end up with the DNA sequence in different positions. C.     Over time the expression of an integrated gene will change, usually decreasing.  Describe how you think the cell downregulates expression of an integrated gene.

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Asked Dec 1, 2019
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The goal of most gene therapies is to insert a healthy copy of a gene into the genome.  Besides CRISPR, techniques for integrating DNA into the genome do not target that DNA to a particular genomic location and thus different cells end up with the DNA sequence in different positions.

 C.     Over time the expression of an integrated gene will change, usually decreasing.  Describe how you think the cell downregulates expression of an integrated gene.

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Expert Answer

Step 1

Genome editing or gene editing is a collection of technologies that enable the researchers to modify the DNA of an organism. These technologies enable genetic material to be joined, eliminated, or modified. Several strategies for genome editing have been developed. A modern one is called CRISPR-Cas9 that modifies DNA at particular locations in the genome. The CRISPR-Cas9 system is faster, cheaper, more reliable, and more effective than previous genome editing techniques.

Step 2

In previous methods, transfection or introducing a foreign gene into the genome, with an altered gene usually leads to gene addition rather than gene replacement. The altered gene is inserted at a random location in the genome so that the cell has the additional mutated gene to its usual gene copies.

So the additional random integra...

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