The goal of most gene therapies is to insert a healthy copy of a gene into the genome.  Besides CRISPR, techniques for integrating DNA into the genome do not target that DNA to a particular genomic location and thus different cells end up with the DNA sequence in different positions.C. Over time the expression of an integrated gene will change, usually decreasing.  Describe how you think the cell downregulates expression of an integrated gene.

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Asked Dec 3, 2019
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The goal of most gene therapies is to insert a healthy copy of a gene into the genome.  Besides CRISPR, techniques for integrating DNA into the genome do not target that DNA to a particular genomic location and thus different cells end up with the DNA sequence in different positions.

C. Over time the expression of an integrated gene will change, usually decreasing.  Describe how you think the cell downregulates expression of an integrated gene.

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Expert Answer

Step 1
  • The expression of a transgene depends on its site of integration, state of differentiation of target cells, and features of the transgene cassette.
  • The gene expression pattern that is pre-existing in the target cells can affect the expression of transgene and suppress the signal from transgene’s regulatory elements. The progressi...

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