The initial population consists of 60% AaBb and 40 % aabb. Find the linkage disequilibrium value after two generations of random mating if a) the two loci are independent b) two loci are linked with r=20%
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- For a simulated population in AlleleA1 to be in Hardy-Weinberg equilibrium, the mutation rate would need to be set at: A. 0. B. 0.1. C. 0.01. D. 0.001Two SNPs are located in the short arm of chromosome 12. SNP1 has allele frequencies of 60% T and 40% C, and SNP2 has allele frequencies of 40% A and 60% G. What is the frequency of the haplotype T-G in a population if the two SNPs are in absolute linkage disequilibrium and if they are in linkage equilibrium?What is the expected genotype frequency of the heterozygous genotype under the Hardy-Weinberg equation P = 0.7?
- A population sample of 300 individuals is studied for the electrophoretic mobility of an enzyme that varies according to the genotype determined by 2 alleles, E and T of a single gene. The results are 7 individuals with genotype EE, 106 with genotype ET, and 187 with genotype TT. What are the allele frequencies of E and T, and what are the expected numbers of the 3 genotypes if random mating is assumed?Three linked loci A, B, C (each with two alleles as in Question 2) in a random mating population havethe gametic frequencies as shown below. Calculate the linkage disequilibium D/Dmax between eachpair of loci. Explain why the results seem paradoxical. [based on Hartl 3rd ed. Q1.15 – try on yourown before checking the answer, and show your calculations for D and Dmax]Gamete ABC ABc AbC Abc aBC aBc abC abcFrequency 0.25 0 0.25 0 0 0.25 0 0.25 respectivelyUsing the product rule, what is the total frequency of the profile, given the following genotype frequencies for each of the loci: D3S1358 = 0.04453 vWA = 0.02725 D5S818 = 0.07534 0.008406 0.0000914 0.14712 10,491 0.914208
- If a population is in Hardy-Weinberg equilibrium for the multiple alleles A+, A and a, whose frequencies are p= 0.60 for A+, q= 0.20 for A, and r = 0.20 for a, what percentage of the population is expected to be heterozygous?If two loci R/r and W/w are linked and are 14 map units apart, and an RW/rw individual is testcrossed, you will obtain: Group of answer choices 1)7% RW individuals 2)86% Rw individuals 3)14% RW individuals 4)14% rW individuals 5)43% rw individualsThe M and N blood groups are determined by two codominant alleles. In a random sample of 200 persons, 128 were found to belong to group M. Assuming random mating, what is the frequency of the N allele?
- What is the expected total time of the coalescent (TC) for a sample of 3 alleles? If there were 5 generations per year and an N of 100, what would be the (TC) in years?Snow geese (Chen caerulescens) come in two color types, white “snows” and “blues” with dark bodies. A single gene controls coloration, where the dark (“blue”) allele (D) is dominant. Researchers using genetic testing are able to determine the following numbers of individuals of each genotype in another population of geese: DD = 10576, Dd = 14503, dd = 4922. -According to the Hardy-Weinberg equilibrium, what is the expected number of individuals of genotype DD? -Calculate the chi-square statistic from these data. What is the value of the chi-square statistic?Applying Hardy-Weinberg equilibrium. For instance, within a given sample population, you have p = 0.3. what would be the expected frequency of heterozygotes for the involved allelic pair?