The purinosome contains enzymes that convert the serine hydroxymethyl group to the formyl group of 10-formyltetrahydrofolate. Write a balanced equation for each reaction in this conversion.
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- The purinosome contains enzymes that convert the serine hydroxymethylgroup to the formyl group of 10-formyltetrahydrofolate. Write a balancedequation for each reaction in this conversion.Explain the chemical change that occurs in converting kynurenine (a product of tryptophan degradation) to kynurenate, a reaction in which α-ketoglutarate is transformed to glutamate.Dihydrouracil and β-ureidopropionate (N-carbamoyl–β-alanine) are intermediates in the conversion of uracil to β-alanine. Provide the structures of the molecules in this pathway.
- A pentapeptide was found to have the composition Ala Arg Gly Pro Trp. Reaction of the pentapeptide with Sanger’s reagent, followed by hydrolysis, gave the DNP derivative of proline. Treatment of the pentapeptide with carboxypeptidase initially produced alanine. Treatment of the pentapeptide with trypsin gave a tetrapeptide which, when treated with chymotrypsin, produced a tripeptide. What is the sequence of the pentapeptide? (note: trypsin cleaves after basic amino acids) *An inhibitor that specifically labels chymotrypsin at histidine 57 is Ntosylamido-l-phenylethyl chloromethyl ketone. How would you modify the structure of this inhibitor to label the active site of trypsin?The sucrose substitute tagatose is produced by hydrolyzing lactose and then chemically converting one of the two resulting aldoses to a ketose. Which residue of lactose gives rise to tagatose?
- D-Talose is a C2 epimer of D-galactose. Using the Fischer projection structure, draw the product of reaction ofD-talose with the given reagent or enzyme and write the systematic name of the product. 1. 2,4-DNP 2. Reaction with aminotransferase and then acetyltransferase at C4As a substituent, the hydrocarbon “tail” of the Ibuprofen molecule (see circle above) can be best described as n-butyl.  sec-butyl. isobutyl. tert-butylWhy is phenylketonuria resulting from dihydropteridine reductase deficiency a more serious disorder than PKU resulting from phenylalaninehydroxylase deficiency?
- An inhibitor that specifically labels chymotrypsin at histidine 57 is N-tosylamido-l-phenylethyl chloromethylketone. How would you modify the structure of this inhibitor tolabel the active site of trypsin?N -Acetylglutamate is required as a cofactor in the synthesis of carbamoyl phosphate. How is Nacetylglutamate synthesized from glutamate?Normal cells die in a nutrient medium containing thymidine and methotrexate, whereas mutant cells defective in thymidylate synthase survive and grow. Explain.