Based on the information in Figure 12-6, how doesGal4 regulate four different GAL genes at the sametime? Contrast this mechanism with how the Lac repressor controls the expression of three genes. Transcriptional activator proteins bind to UAS elements in yeastGal4Chr II 5GAL7GAL10GAL13'Chr XII 5GAL23'UASUASUÁSat a considerable linear distance from a eukaryotic gene's promoter is typical.Because the Gal4-activated enhancers are located upstream (5') of the genes theyregulate, they are also called upstream activation sequences (UAS).FIGURE 12-6 The Gal4 proteinactivates target genes through upstream-activating-sequence (UAS) elements. TheGal4 protein has two functional domains:a DNA-binding domain (pink square) andan activation domain (orange oval). Theprotein binds as a dimer to specificsequences upstream of the promoters ofGal-pathway genes. Some of the GALgenes are adjacent (GAL1, GAL10),whereas others are on differentchromosomes. The GAL1 UAS elementKEY CONCEPT The binding of sequence-specific DNA-binding proteins toregions outside the promoters of target genes is a common feature of eukaryotictranscriptional regulation.The Gal4 protein has separable DNA-bindingand activation domainscontains four Gal4-binding sites.

Name: Based on the information in Figure 12-6, how doesGal4 regulate four di
Uploaded: 2024-03-20T06:42:41.000Z
Channel: Bartleby
Description: Based on the information in Figure 12-6, how doesGal4 regulate four different GAL genes at the sametime? Contrast this mechanism with how the Lac repressor controls the expression of three genes. Transcriptional activator proteins bind to UAS element