What is the significance of the ΔG°’ value of each step of Glycolysis? Why do some values classify reactions as irreversible and others as easily reversible?
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A:
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Q: At what point in glycolysis are all the reactions considered doubled?
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What is the significance of the ΔG°’ value of each step of Glycolysis? Why do some values classify reactions as irreversible and others as easily reversible?
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- At what point in glycolysis are all the reactions considered doubled?How many total (NOT NET) molecules of ATP are synthesized from ADP via glycolysis of a single molecule of glucose? Explain by detailing the reactions (steps) involved.Under standard conditions, is the oxidation of ubiquinol (Coenzyme Q) by O2 sufficiently exergonic to drive the synthesis of ATP? If yes, how many ATP can be synthesized assuming 100% efficiency?
- What energetic barrier prevents glycolysis from simply running in reverse to synthesis glucose? What is the energetic cost to overcome this barrier?The free energy change of each step of glycolysis is given in the table below. ∆G°’ is the free energy under standard conditions (25°C, 1M each reactant, pH 7), while ∆G is the free energy change at presumed physiological conditions. Why must no step have a positive ∆G under physiological conditions?Why is there such a large range of ∆G for the second step of glycolysis?
- Where in the biochemical pathway of cellular respiration (glycolysis, intermediate stage, or citric acid cycle) does each of the following enter: (a) glycerol, (b) fatty acids, and (c) deaminated amino acids?Why does glycolysis require ATP investment on a thermodynamic and molecular level?What if the phosphate group for the glycolysis reaction with enzyme glyceraldehyde 3-phosphate dehydrogenase was from ATP instead of Pi? What would the complete, balanced, net rxn of glycoslysisequation be and how does this impact the overall glycolysis rxn?
- A glucose molecule with its 3rd carbon radiolabelled underwent glycolysis. Which carbon atom in the resultant pyruvate will show radioactivity?Why does PGAL have the highest potential energy of glycolysis?What if the phosphate group for the glycolysis reaction with enzyme glyceraldehyde 3-phosphate dehydrogenase was from ATP instead of Pi? What would the net equation be and how does this impact the glycolysis rxn and cell?