A Moving to another question will save this response.Question 34Which of the following phenotypes is an example of a temperature-sensitive conditional mutation?O Siamese catsO Tay-SachsO PhenylketonuriaO AchoncoplasiaO PorphyriaA Moving to another question will save this response.MacBo* F220F42$234.RAS6LE.

Name: A Moving to another question will save this response.Question 34Which
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Description: A Moving to another question will save this response.Question 34Which of the following phenotypes is an example of a temperature-sensitive conditional mutation?O Siamese catsO Tay-SachsO PhenylketonuriaO AchoncoplasiaO PorphyriaA Moving to another q

Introduction: Mutation refers to the alteration in the nucleotide sequence of the genome in an…

Answered: Which of the following phenotypes is an…

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Biology

Which of the following phenotypes is an example of a temperature-sensitive conditional mutation? Siamese cats O Tay-Sachs O Phenylketonuria O Achoncoplasia O Porphyria

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter11: Genome Alterations: Mutation And Epigenetics

Section: Chapter Questions

Problem 2QP: Achondroplasia is an autosomal dominant form of dwarfism caused by a single gene mutation. Calculate...

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Enhanced Spatial Learning Ability in Mice Engineered to Carry an Autism Mutation Autism is a neurobiological disorder with symptoms that include impaired social interactions and repetitive, stereotyped patterns of behavior. Around 10 percent of autistic people also have an extraordinary skill or talent such as greatly enhanced memory. Mutations in the gene for neuroligin 3, an adhesion protein that connects brain cells, have been associated with autism. One of these mutations is called R451C because the altered gene encodes a protein with an amino acid substitution: a cysteine (C) instead of an arginine (R) in position 451. In 2007, Katsuhiko Tabuchi and his colleagues introduced the R451C mutation into the neuroligin 3 gene of mice. The researchers discovered that the genetically modified mice had impaired social behavior and superior spatial learning ability. Spatial learning in mice is tested with a water maze, which consists of a small platform submerged a bit below the surface or a pool of water so it is invisible to a swimming mouse. Mice do not particularly enjoy swimming, so they try to locate the hidden platform as quickly as they can. When tested again later, they remember the platforms location by checking visual cues around the edge or the pool. How quickly they remember is a measure of their spatial learning ability. FIGURE 15.14 shows some or Tabuchis result. FIGURE 15.14 Spatial learning ability in mice. Mice with a mutation in neuroligin 3 (R451C) were tested for learning performance: as compared with unmodified (wild-type) mice. Did the modified or the unmodified mice learn the location of the platform faster in the first test?
Neanderthal Hair Color The MC1R gene regulates pigmentation in humans (Sections 14.1 and 15.1 revisited), so loss-of-function mutations in this gene affect hair and skin color. A person with two mutated alleles for this gene makes more of the reddish melanin than the brownish melanin, resulting in red hair and pale skin. DNA extracted from two Neanderthal fossils contains a mutated MC1R allele that has not yet been found in humans. To see how the Neanderthal mutation affects the function of the MC1R gene. Carles Lalueza-Fox and her team introduced the allele into cultured monkey cells (FIGURE 26.16). FIGURE 26.16 MC1R activity in monkey cells transgenic for an unmutated MC1R gene, the Neanderthal MC1R allele, or the gene for green fluorescent protein (GFP). GFP is not related to MC1R. 1. How did MCR1 activity in monkey cells with the mutant allele differ from that in cells with the normal allele?
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Question:- Often a given mutation or variant will have slightly different phenotypes in different groups of patients. “Genetic Background” is frequently used to explain how the same exact mutation could exhibit different phenotypes in different populations. Please explain.
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