Answered: Which of the following would be a good…

Which of the following would be a good chemotherapy approach: blocking formation of the ribonucleotide GTP or blocking formation of the deoxyribonucleotide dGTP? Why?

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter28: Dna Metabolism: Replication, Recombination, And Repair

Section: Chapter Questions

Problem 21P

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Concept explainers

Genomics

Genes are responsible for transmitting the characters located on the chromosomes from one individual to another across the generations. Genetics is the study of different genes that are involved in different functions. Genetics is a branch of biology that studies genes, genetic diversity, and heredity in living organisms. The genetic system consists of genetic notations, which is a system of signs and symbols. Genotype refers to the organism's genetic composition, and phenotype refers to the observable property of the organism.

Question

Which of the following would be a good chemotherapy approach: blocking formation
of the ribonucleotide GTP or blocking formation of the deoxyribonucleotide dGTP?
Why?

Please explain the chemical differences between each of the two nucleotides. Use the specific processes below to support your choice by explaining how either GTP or dGTP
are related to these and how loss of the particular molecule would affect each process.

*PEP carboxykinase in gluconeogenesis
*Succinyl-CoA synthetase in the TCA Cycle
*Glucagon signal transduction

Definition Definition A complex molecule that makes up a fundamental unit of a DNA or RNA molecule. Nucleotides are composed of a sugar, a nitrogenous base, and a phosphoric acid.

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