Based on its molecular structure what would you expect to be the biological mechanism of thehypothetical anti-cancer drug shown below.OHOMeOMe öHỌ HỌPlease choose one:a. DNA intercalationb. Dihydrofolate reductase inhibitionc. DNA strand breakingD. DNA alkylationto Estrogen eceptor modulation

Anticancer drugs are those that can treat malignant diseases. There are several kinds of anticancer…

Answered: Based on its molecular structure what…

Essentials of Pharmacology for Health Professions

7th Edition

ISBN:9781305441620

Author:WOODROW

Publisher:WOODROW

Chapter14: Antineoplastic Drugs

Section: Chapter Questions

Problem 11CRQ

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1. Below is the abstract from a journal article “De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase” by Vertino et al. Read it and answer the following questions. Recent studies showing a correlation between the levels of DNA (cytosine-5-)-methyltransferase (DNA MTase) enzyme activity and tumorigenicity have implicated this enzyme in the carcinogenic process. Moreover, hypermethylation of CpG island-containing promoters is associated with the inactivation of genes important to tumor initiation and progression. One proposed role for DNA MTase in tumorigenesis is therefore a direct role in the de novo methylation of these otherwise unmethylated CpG islands. In this study, we sought to determine whether increased levels of DNA MTase could directly affect CpG island methylation. A full-length cDNA for human DNA MTase driven by the cytomegalovirus promoter was constitutively expressed in human fibroblasts. Individual clones…
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Based on its molecular structure what would you expect to be the biological mechanism of the hypothetical anti-cancer drug shown below. OMe OMe ö OH OH Please choose one: a DNA intercalation b. Dihydrofolate reductase inhibition e DNA strand breaking D DNA alkylation to Estrogen receptor ooulation