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- If the frequency of those exhibiting a monogenic autosomal recessive phenotype caused by only one known clinically relevant allele is 1/8500 in a given population, what is the frequency of the wild type allele? Please give your answer as a percentage to 3 decimal places, do not include the % symbol.Cystic fibrosis is an autosomal recessive disease characterized by two copies of a mutated CFTR gene. If one in 100 (hypothetical scenario, not reality) people in the United States have cystic fibrosis, calculate the p and q frequency for the normal allele (p) and the mutated allele (q). Based on those calculations, what percentage of individuals would be expected to be homozygous dominant?Cystic fibrosis is an autosomal recessive disorder that affects 1 in 3 000 newborns with Caucasian background. It causes thick mucus build up in various organs and can cause damages and problems in respiratory and digestive systems. a) What is the frequency of the cystic fibrosis allele in the Caucasian population? Show all your work and express your answer as a value between 0 and 1 rounded to two decimal places. b) What percentage of the Caucasian population would be carriers for cystic fibrosis? Show all your work and express your answer rounded to two decimal places. c)If two individuals are carriers of the cystic fibrosis allele, what is the probability that they would have a girl without cystic fibrosis? Show all your work (including the Punnett square) and express your answer as a value between 0 and 1 rounded to two decimal places.
- 1.) Cystic fibrosis is an inherited recessive disorder that causes especially thick mucus to build up in the lungs and digestive tract. The mucus makes it difficult to clear micro-organisms from the airways, so people with cystic fibrosis are prone to dangerous respiratory infections. Among Caucasians, about one in every 3000 newborns is affected by this condition. Determine the frequency of the cystic fibrosis allele among Caucasians. What proportion of this population would you expect to be heterozygous carriers of the cystic fibrosis allele? Express your answers as decimals.In the genetics unit you learned that sickle cell anemia is an autosomal recessive condition. In 2016, assume in the City of Markham there are 1000 people out of 300000 people who have sickle cell anemia. Assume global warming continues for the next 50 years and in the year 2066 there are 20000 people out of 500000 in Markham who have sickle cell anemia. a)What are the allele frequencies in 2016? What are the allele frequencies in 2066? Is microevolution evident? b)Due to global warming, assume the numbers of malaria carrying mosquitoes in Markham dramatically increased between 2016 and 2066. What do you believe is the main cause of the microevolution in Markham? (Hint- refer to the 5 factors affecting microevolution and refer back…The equation p2+ 2pq + q2= 1 representing theHardy-Weinberg proportions examines genes withonly two alleles in a population.a. Derive a similar equation describing the equilibrium proportions of genotypes for a gene withthree alleles. [Hint: Remember that the HardyWeinberg equation can be written as the binomialexpansion (p + q)2.]b. A single gene with three alleles (IA, IB, and i) isresponsible for the ABO blood groups. Individualswith blood type A can be either IA IAor IA i;those with blood type B can be either IB IBor IB i;people with AB blood are IA IB, and type O individuals are ii. Among Armenians, the frequency of IAis0.360, the frequency of IBis 0.104, and the frequencyof i is 0.536. Calculate the frequencies of individuals in this population with the four possible bloodtypes, assuming Hardy-Weinberg equilibrium.In Problems 15–17, you will see that because matingbetween individuals within populations at Hardy-Weinbergequilibrium is random, it is possible to predict…
- Please read the scenario below, and then answer the question (in bold) that follows. Tay-Sachs disease is a fatal autosomal recessive disorder in children (usually by age 5) that causes a progressive degeneration of the central nervous system. This disease affects 1 in 3,500 newborns of European Ashkenazi Jewish ancestry in the U.S. population. What is the number of carriers in the population? a. 1 person b. 60 persons c. 116 persons d. 3,383 persons e. 3,441 personsTay–Sachs disease is an autosomal recessive disorder. Among Ashkenazi Jews, the frequency of Tay–Sachs disease is 1 in 3600. Assuming the Ashkenazi population is in Hardy-Weinberg equilibrium, what proportion of the population is expected to be carriers (e.g. heterozygous) for the Tay–Sachs allele?Cystic fibrosis (CF) is an autosomal recessive disorderthat occurs relatively frequently among people ofEuropean descent. In an Amish community in Ohio,medical researchers reported the occurrence of cysticfibrosis (CF) as being 1/569 live births. Using theHardy–Weinberg rule, estimate the frequency of carriers of the disease allele in this Amish population.
- In a large, randomly mating population, the frequency of the allele (s)for sickle-cell hemoglobin is 0.028. The results of studies have shownthat people with the following genotypes at the beta-chain locus producethe following average numbers of offspring:Genotype Average numberof offspring producedSS 5Ss 6ss 0a. What will the frequency of the sickle-cell allele (s) be in the nextgeneration?b. What will the frequency of the sickle-cell allele be at equilibrium?46. In a hypothetical population, a genetic anthropologist has gone in and determined the following genotypes and genotype frequencies for earlobe attachment. From this data, this scientist wants to determine gene frequencies at this locus for the dominant and recessive alleles. Unattached earlobes (E) are the dominant form of the trait while attached earlobes (e) are the recessive form of the trait. At this particular gene locus, the following genotype distribution was determined: (1) dominant homozygote (EE) = 0. 16 (or 16 percent of the individuals are dominant homozygotes for this trait and have unattached earlobes) (2) heterozygote (Ee = 0.48 (or 48 percent of the individuals in this population is heterozygous at this locus and have unattached earlobes) (3) recessive homozygote (ee) = 0.36 (or 36 percent of the individuals in this population are recessive homozygotes and have attached earlobes)...What is the frequency of the dominant allele? * a. 20% b. 30% c. 35% d. 40% e. 60% f.…As it turned out, one of the tallest Potsdam Guards had an unquenchable attraction to short women. During his tenure as guard, he had numerous clandestine affairs. In each case, children resulted. Subsequently, some of the childrenwho had no way of knowing that they were relatedmarried and had children of their own. Assume that two pairs of genes determine height. The genotype of the 7-foot-tall Potsdam Guard was A9A9B9B9, and the genotype of all of his 5-foot clandestine lovers was AABB. An A9 or B9 allele in the offspring each adds 6 inches to the base height of 5 feet conferred by the AABB genotype. a. What were the genotypes and phenotypes of all the F1 children? b. Diagram the cross between the F1 offspring, and give all possible genotypes and phenotypes of the F2 progeny