You have created three different mutations in the histoneH1 protein (HISmut1, HISmut2, HISmut3), and each of these mutations eliminate a stretch of 5 amino acids from the primary sequence. Based on the description of where you find the mutant histoneH1 proteins when you look inside a cell in each of the cases below, describe 1) what the function is of the amino acids that were removed, and 2) what is not happening with the mutant histoneH1 protein that does happen with wild type H1: 1.  HISmut2 protein is found in the cytoplasm, and never in the nucleus. 2.  HISmut1 protein is found in only briefly in the cytoplasm because it is very quickly sent to the proteasome. 3.  HISmut3 protein is found floating freely throughout the nucleoplasm.

Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter10: From Proteins To Phenotypes
Section: Chapter Questions
Problem 20QP: If an extra nucleotide is inserted in the first exon of the beta globin gene, what effect will it...
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You have created three different mutations in the histoneH1 protein (HISmut1, HISmut2, HISmut3), and each of these mutations eliminate a stretch of 5 amino acids from the primary sequence. Based on the description of where you find the mutant histoneH1 proteins when you look inside a cell in each of the cases below, describe 1) what the function is of the amino acids that were removed, and 2) what is not happening with the mutant histoneH1 protein that does happen with wild type H1:

1.  HISmut2 protein is found in the cytoplasm, and never in the nucleus.

2.  HISmut1 protein is found in only briefly in the cytoplasm because it is very quickly sent to the proteasome.

3.  HISmut3 protein is found floating freely throughout the nucleoplasm.

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