Answered: Lysine 4 of histone H3 (H3K4) is…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Question

Lysine 4 of histone H3 (H3K4) is methylated in the
nucleosomes of many transcriptionally active genes.
Suppose you want to determine all the places in the
human genome where nucleosomes contain methylated H3K4.
a. Starting with an antibody that specifically binds
only to the tails of histone H3s that have K4 methylation, what kind of experiment would you perform? Outline the major steps of this experiment.
b. Do you think that you would get the same results if
your starting material was skin cells in one experiment and blood precursor cells in a second experiment? Explain.
c. Describe a follow-up experiment that could determine if your data from part (a) are consistent with
the idea that H3K4 methylation marks appear only
at transcriptionally active genes

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