You identify a disease of epidermal cells in mice in which Gene A is not expressed. Further analysis reveals that the sequence of Gene A in affected and normal mice is the SAME. Which of the statements below could explain why Gene A is NOT expressed in the epidermal cells of the affected mice. Select all that apply? Tyrosine residues are phosphorylated in histone tails close to Gene A in normal mice but not in affected mice Lysine residues are acetylated in histone tails close to Gene A in normal mice but not in affected mice Epidermal cells of affected mice lack the transcription factors associated with Gene A. DNA in the promoter region of Gene A of affected mice is highly methylated

You identify a disease of epidermal cells in mice in which Gene A is not expressed. Further analysis reveals that the sequence of Gene A in affected and normal mice is the SAME. Which of the statements below could explain why Gene A is NOT expressed in the epidermal cells of the affected mice. Select all that apply? Tyrosine residues are phosphorylated in histone tails close to Gene A in normal mice but not in affected mice Lysine residues are acetylated in histone tails close to Gene A in normal mice but not in affected mice Epidermal cells of affected mice lack the transcription factors associated with Gene A. DNA in the promoter region of Gene A of affected mice is highly methylated

Name: You identify a disease of epidermal cells in mice in which Gene A is
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Description: You identify a disease of epidermal cells in mice in which Gene A is not expressed.Further analysis reveals that the sequence of Gene A in affected and normal mice isthe SAME.Which of the statements below could explain why Gene A is NOT expressed in

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter11: Genome Alterations: Mutation And Epigenetics

Section: Chapter Questions

Problem 10QP: If the coding region of a gene (the exons) contains 2,100 base pairs of DNA, would a missense...

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Recently, scientists constructed a transgene that expresses a mutant form of Drosophila histone H3 inwhich lysine 27 in the histone tail was changed to methionine (H3K27M). Expression of the H3K27Mtransgene results in aberrant development of fruit fliesbecause of inappropriate expression of many differentgenes. Explain this finding.
Examination of the histone modifications around a gene reveals an abundance of histone H3 with lysine 27 modified with three methyl groups. Does this suggest that this gene is activated or repressed? How would your answer change if many lysine 27 residues were modified with acetyl groups?
Homozygosity for extremely rare mutations in a humangene called SCN9A cause complete insensitivity topain (congenital pain insensitivity or CPA) and a totallack of the sense of smell (anosmia). The SCN9A geneencodes a sodium channel protein required for transmission of electrical signals from particular nerves inthe body to the brain. The failure to feel pain is a dangerous condition as people cannot sense injuries.The SCN9A gene has 26 exons and encodes a1977-amino acid polypeptide. Consanguineous matings in three different families have resulted in individuals with CPA/anosmia. In Family 1, a G-to-Atransition in exon 15 results in a truncated protein that is898 amino acids long; in Family 2, deletion of a singlebase results in a 766-amino acid polypeptide; and inFamily 3, a C-to-G transversion in exon 10 yields a458-amino acid protein.a. Hypothesize as to how each of the three SCN9Amutations affects gene structure: Why are truncatedproteins made in each case? b. How would you…
If the coding region of a gene (the exons) contains 2,100 base pairs of DNA, would a missense mutation cause a protein to be shorter, longer, or the same length as the normal 700 amino acid proteins? What would be the effect of a nonsense mutation? A sense mutation?
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A genon wide analyst of human genome indicated that approximately 1500 genes encoded transcription factors that are important for sequence specific gene expression. based on this information approximately what percentage of the protein coding genes in human belong to the transcription factors? A. 15% B. 5% C. 7.5% D.1.5%
Melanosomes are specialized lysosomes that storepigments for eventual release by exocytosis. Various cellssuch as skin and hair cells then take up the pigment, whichaccounts for their characteristic pigmentation. Mousemutants that have defective melanosomes often have paleor unusual coat colors. One such light-colored mouse, theMocha mouse (Figure Q13–3), has a defect in the gene forone of the subunits of the adaptor protein complex AP3,which is associated with coated vesicles budding from thetrans Golgi network. How might the loss of AP3 cause adefect in melanosomes?
A human gene called theCFTR gene (for cystic fibrosis transmembrane regulator) encodes aprotein that functions in the transport of chloride ions across the cellmembrane. Most people have two copies of a functional CFTR geneand do not have cystic fibrosis. However, a mutant version of the CFTRgene is found in some people. If a person has two mutant copies ofthe gene, he or she develops the disease known as cystic fibrosis. Arethe following descriptions of this disease related to genetics at themolecular, cellular, organism, or population level?A. People with cystic fibrosis have lung problems due to a buildupof thick mucus in their lungs.B. The mutant CFTR gene encodes a defective chloride transporter.C. A defect in the chloride transporter causes a salt imbalance inlung cells.D. Scientists have wondered why the mutant CFTR gene is relativelycommon. In fact, it is the most common mutant gene that causesa severe disease in persons of Northern European descent. Onepossible explanation why…