HUMAN BIOLOGY: CONCEPTS - 9780134312729
8th Edition
ISBN: 2819260095972
Author: Johnson
Publisher: PERUSALL
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Chapter 10, Problem 10TY
Summary Introduction
Introduction:
Hemoglobin refers to an iron consisting oxygen-carrying metalloprotein present in the RBCs (red blood cells) of almost all the vertebrate and some invertebrates. This is responsible for carrying the O2 (oxygen) from the lungs to the rest of the parts of the body. In tissues, it releases the oxygen, which allows the aerobic respiration to occur in order to supply energy to power the functions of the organism and this process is known as
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Which of the following does not happen at the O₂ binding site of hemoglobin (Hb)?
1) Movement of the metal co-factor
II) Protonation of the proximal His
III) The spin state change of the Fe2+ ion
IV) Change of shape of the protoporphyrin IX ring
OI
ON
O III
Oll
Consider this figure, which shows oxygen binding to hemoglobin under various
conditions
1.0
В
A
0.5-
pO2
a) If B is normal hemoglobin what could lead to curve hemoglobin A.
b) If B is normal hemoglobin what could lead to curve hemoglobin C.
c) Which curve shows the hemoglobin with the highest O2 affinity?
d) Which curve shows the hemoglobin with the lowest P50?
(Saturation)
1.
a) True or False - A mutation in the beta globin gene that causes conversion of His146 to Glutamate would decrease Hemoglobin’s O2 binding affinity.
b) True or False - A mutation in the beta globin gene that causes conversion of His146 to Glutamate would eliminate Hemoglobin’s positive cooperativity.
Chapter 10 Solutions
HUMAN BIOLOGY: CONCEPTS - 9780134312729
Ch. 10 - Do you think e-cigarettes should be regulated, and...Ch. 10 - What safety concerns do you have, if any, about...Ch. 10 - List at least three functions of your nose.Ch. 10 - Prob. 2CRCh. 10 - Prob. 3CRCh. 10 - Prob. 4CRCh. 10 -
5. Explain what happens to gas pressure in a...Ch. 10 - Prob. 6CRCh. 10 - Prob. 7CRCh. 10 - Prob. 8CR
Ch. 10 - Prob. 9CRCh. 10 - Prob. 10CRCh. 10 - Which of the following lists the order of...Ch. 10 - Prob. 2TYCh. 10 - Much of the respiratory tract is lined with...Ch. 10 - Prob. 4TYCh. 10 - Prob. 5TYCh. 10 - Prob. 6TYCh. 10 - Prob. 7TYCh. 10 -
8. During a breathing cycle, as the diaphragm and...Ch. 10 - Prob. 9TYCh. 10 - Prob. 10TYCh. 10 - Prob. 11TYCh. 10 - Prob. 12TYCh. 10 - Prob. 13TYCh. 10 - Prob. 14TYCh. 10 - Prob. 15TYCh. 10 - Why would someone administering a Breathalyzer...Ch. 10 -
2. At a murder trial, a pathologist is asked...Ch. 10 - Prob. 3AWKCh. 10 - Prob. 4AWKCh. 10 - Prob. 5AWKCh. 10 - Prob. 6AWKCh. 10 - Prob. 7AWK
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- Below is the equation that represents O2 binding to hemoglobin. Hb+4O2⇌Hb(O2)According to Le Chatelier’s principle, which form of the hemoglobin (Hb or Hb(O2)4) is predominant in the lungs where the partial pressure of oxygen is high? Explain. I need help answering thisarrow_forwardWhich one of the following statements concerning Hb (hemoglobin) A1c is CORRECT? Question 4 options: a) HbA1c contains glucose molecules b) The concentration of HbA1c in the red blood cells (RBCs) decreases as RBCs age in the circulation c) Insulin injection can decrease the amount of HbA1c in the blood d) Weight is correlated with HbA1c concentrationarrow_forwardWhich of the following statements is true for Bohr effect: a. Bohr effect describes carbon monoxide poisoning. b. Bohr effect prevents oxygen binding to hemoglobin. c. Bohr effect allows effective oxygen discharge in tissues due to higher acidity (decreased pH) than in lungs. d. Bohr effect allows effective oxygen discharge in tissues due to lower acidity (increased pH) than in lungs.arrow_forward
- Choose the factors that favor LOADING of oxygen onto hemoglobin. a) higher PO b) higher pH c) lower PCO d) lower BPG e) all of the abovearrow_forwardIn addition to O2 binding, changes in other chemical conditions can result in changes in hemoglobin structure and function. Increases in blood H+ result in oxygen binding curves for hemoglobin that are shifted to the right. The effect of H+ can be understood in terms of the equilibrium:H-Hb+ + O2 → Hb-O2 + H+How does the difference in pH in the lungs and tissues help hemoglobin do its job of delivering oxygen? Use the equilibrium equation in your argument.arrow_forwardWhich of the following statements is false concerning the structure of hemoglobin? a. The binding of BPG stabilizes the T-state of Hb b. The R-state of Hb is favored under environments of high concentrations of O2 c. Hemoglobin's affinity for oxygen increases as protons ionize from the N-terminal tails d. Hemoglobin is stabilized in the low affinity state in the presence of high concentration of protons e. Hemoglobin favors the R-state in basic environmentsarrow_forward
- Which of the following stabilize the hemoglobin quaternary structure of low-affinity to oxygen molecules? Group of answer choices a. CO b. CO2 c. bisphosphoglycerate d. H+arrow_forwardAll of the following are accurate statements about hemoglobin except a. hemoglobin carries oxygen on the Fe ion. b. hemoglobin carries carbon dioxide on the globin. c. hemoglobin carries only a small portion of the total carbon dioxide in the blood (less than 25%). d. hemoglobin releases oxygen at the level of the cell, making hemoglobin more saturated.arrow_forwardWhich of the following concerning hemoglobin is true? a) BPG decreases at high altitudes and causes more O2 offloading in tissues b) As pH increases, [CO2] increases in tissues, causing more O2 release in tissue c) The R state is stabilized by CO2 binding, whereas the T state is stabilized by O2 binding d) About 38% of oxygen dissociates from hemoglobin in tissues e) Hemoglobin has a higher affinity for oxygen than carbon monoxide My guess is D.arrow_forward
- Which of the following concerning hemoglobin is true? a) BPG decreases at high altitudes and causes more O2 offloading in tissues b) As pH increases, [CO2] increases in tissues, causing more O2 release in tissue c) The R state is stabilized by CO2 binding, whereas the T state is stabilized by O2 binding d) About 38% of oxygen dissociates from hemoglobin in tissues e) Hemoglobin has a higher affinity for oxygen than carbon monoxide My guess is D. What following statement is TRUE concerning motifs and domains? a) Both motifs and domains are independently stable. b) Domains undergo dynamic individual changes that affect the entire protein c) B-a-ß loops, B barrels, and helix-turn-helix structure are types of domains d) Motifs and domains are part of secondary structural elements e) Ab initio computations predict motif folds accurately a majority of the time My guess is B. Which of the following is TRUE under the following conditions: an enzyme displaying Michaelis-Menten kinetics…arrow_forwardWhich of the following statements are TRUE: Very low oxygen levels will cause: a) Myoglobin instead of hemeglobin will be used to transfer oxygen to cells b) You might experience feelings similar to sickle-cell anemia c) You might have a higher total concentration of hemeglobin to help transport enough oxygen. d) Oxygen will be more concentrated in the air, resulting in higher saturation of hemeglobinarrow_forwardWhich of the following scenariosare correct?Select all that apply A. High levels of PCO2will cause loading of O2ontohemoglobin. B. An increase in pH will causeO2to unload from hemoglobin. C. High PO2levels will increase saturation of Hb with O2. D. An increase in bodytemperature will cause O2to unload from hemoglobin.arrow_forward
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