BIOLOGY 11E CHAPTERS 1-19
11th Edition
ISBN: 9781307365849
Author: Raven
Publisher: MCG CUSTOM
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Textbook Question
Chapter 10, Problem 1A
Cyclin-dependent kinases (Cdks) are regulated by
a. the periodic destruction of cyclins.
b. bipolar attachment of chromosomes to the spindle.
c. DNA synthesis.
d. Both a and b are correct.
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Students have asked these similar questions
Which of the following statements is a lie?Select one:
a. If damaged DNA is detected during the cell cycle, negative regulation is responsible in stopping the cell cycle.
b. There are four cyclin proteins involved in the positive regulation of the cell cycle and they have fluctuating levels.
c. To activate cyclin-dependent kinases (Cdks), they must bind to another kinase.
Which of the following is the primary method by which cyclin proteins are regulated to influence entry into the cell cycle or transition from one stage to the next?
A.
Transcriptional upregulation and translation followed by targeted ubiquitin-mediated degradation by a proteasome.
B.
Phosphorylation to regulate the activity of the kinase site.
C.
An activating phosphorylation and an inactivating phosphorylation.
D.
All of these are mechanisms that can be used to regulate cyclins.
Vinblastine is a standard chemotherapeutic drug used to treat cancer. Because it
interferes with the assembly of microtubules, its effectiveness must be related to
Select one:
a. inhibition of DNA synthesis.
O b. myosin denaturation and inhibition of cleavage furrow formation.
c.
suppression of cyclin production.
Od. inhibition of regulatory protein phosphorylation.
O e. disruption of mitotic spindle formation.
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Chapter 10 Solutions
BIOLOGY 11E CHAPTERS 1-19
Ch. 10 - Binary fission in prokaryotes does not require the...Ch. 10 - Chromatin is composed of a. RNA and protein. b....Ch. 10 - What is a nucleosome? a. A region in the cells...Ch. 10 - What is the role of cohesin proteins in cell...Ch. 10 - The kinetochore is a structure that functions to...Ch. 10 - Separation of the sister chromatids occurs during...Ch. 10 - Why is cytokinesis an important part of cell...Ch. 10 - What steps in the cell cycle represent...Ch. 10 - Cyclin-dependent kinases (Cdks) are regulated by...Ch. 10 - Prob. 2A
Ch. 10 - Genetically, proto-oncogenes act in a dominant...Ch. 10 - The metaphase to anaphase transition involves a....Ch. 10 - The main difference between bacterial cell...Ch. 10 - In animal cells, cytokinesis is accomplished by a...Ch. 10 - Regulation of the cell cycle is very complex and...Ch. 10 - Review you knowledge of signaling pathways...Ch. 10 - Compare and contrast how mutations in cellular...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Predict the effects of the following mutations on the ability of a cell to undergo apoptosis:a. Mutation in Bad such that it cannot be phosphorylated by protein kinase B (PKB)b. Overexpression of Bcl-2c. Mutation in Bax such that it cannot form homodimersOne common characteristic of cancer cells is a loss of function in the apoptotic pathway. Which of the mutations listed above might you expect to find in some cancer cells?arrow_forwardA drug that inhibits the kinase activity of AKT would MOST likely have which of the following effects? A. Increased GSK-3b activity and increased CyclinD synthesis B. Increased GSK-3b activity and decreased CyclinD synthesis C. Decreased GSK-3b activity and increased CyclinD synthesis D. Decrease GSK-3b activity and decreased CyclinD synthesisarrow_forwardCyclins and cyclin-dependent kinases regulate progression through the cell cycle. Which of the following determines progression beyond the restriction point in G1? Select one: a. The presence of cyclin and Cdk. O b. The presence of cyclin. c. Phosphorylation of RB by Cdk. d. The presence of external signals from growth factors. e. The absence of cyclin.arrow_forward
- Cell cycle regulation is important to ensure that a. non-dividing cells enter the G0 stage. b. dividing cells produce normal and viable daughter cells. c. the stages in both interphase and M phase are strictly followed. d. materials for cell division are complete and properly distributed. Which of the following complexes contributes to the transcription of cyclin E? a. Cdk1/cyclin A b. Cdk2/cyclin B c. Cdk3/cyclin C d. Cdk4/cyclin Darrow_forwardWhich of the following is a change to the CdK/cyclin system that could result in cell division followed by cell death? Group of answer choices A. Increased production of CdK B. Decreased production of cyclin during G2 C. Increased production of cyclin during G2 D. Cyclin not broken down by mitosis E. Breakdown of CdK by mitosisarrow_forwardIdentify which of the following statements is a lie? Select one: a. A signalling pathway called MAPK/ERK pathway regulates protein translation. b. 2. Two enzymes are phosphorylated by protein kinase A. c. Under normal conditions, cells can divide even without signals from other cells.arrow_forward
- What is the difference between cyclins and kinase proteins? A. Kinases regulates MPF dimer formation and cyclins phosphorylates the kinases in a negative feedback loop B. Cyclins regulate cell cycle, while kinases are enzymes that catalyze phosphorylation of cyclins C. Kinases are enzymes that convert MPF into CDK and the cyclins bind to CDK to send cells into M phase D. Cyclins are enzymes and kinase are proteins that regulate M phasearrow_forwardA researcher studying a line of cancer cells noticed that cellular content of RhoBTB3 and Cyclin E1 increase and decrease through the cell cycle. a. He hypothesizes that RhoBTB3 signaling regulates the production of Cyclin E1 and the entry of the cell into mitosis. Based on the data below, explain why his results do not support this hypothesis. Identify what conclusions are supported by this data. b. Suppose that the researcher can engineer a cell line in which RhoBTB3 expression can be induced by the addition of a drug. Design an experiment using this cell line to test whether RhoBTB3 regulates the production of Cyclin E1. Describe what results he can expect if his hypothesis is correct.arrow_forwardWhen regulating the cell cycle of eukaryotic cells, a critical protein we discussed was cyclin. Cyclin is Select one: a. Always present in all stages of the cell cycle, but only active during the G1 - R transition b. Produced in response to signals for the cell to divide c. Produced only when retinoblastoma protein is inactivated d. Produced in response to the presence of cyclin-dependent kinasearrow_forward
- Lipid-soluble signaling molecules, such as testosterone, cross the membrane of all cells but only affect target cells because a. intracellular receptors are only present in target cells b. only target cells possess the cytosolic enzymes that transduce the testosterone c. target cells are the only cells that can initiate the phosphorylation cascade leading to the transcription factor d. only target cells retain the appropriate DNA segmentsarrow_forwardThe cyclin/cyclin-dependent kinase pair that is active during the M phase of the cell cycle is a.Cyclin A/CDC2. b.Cyclin B/CDC2. c.Cyclin D/CDK4/6. d.Cyclin E/CDK2. e.Cyclin A/CDK2.arrow_forwardOften mutations in cyclin dependent kinases, CDKs, can cause cancer. This is because a. CDKs control the cell cycle progression b. CDKs control apoptosis c. CDKs affect DNA repair d. CDKs affect chromatin remodelingarrow_forward
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