Microbiology: A Systems Approach
Microbiology: A Systems Approach
4th Edition
ISBN: 9780073402437
Author: Marjorie Kelly Cowan Professor
Publisher: McGraw-Hill Education
Question
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Chapter 12, Problem 1CF
Summary Introduction

To determine:

The term “New Delhi metallo-beta-lactamase 1 (NDM-1)”.

Concept introduction:

NDM-1 (New Delhi metallo-beta-lactamase 1) is an enzyme encoded by plasmid, which is able to make bacteria resistant to a wide range of β-lactam antibiotics. This is because the enzyme is able to break the beta-lactam ring of many antibiotics.

Expert Solution
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Explanation of Solution

NDM -1 is also termed as “Indian superbug”. blaNDM-1 is the gene which codes for beta-lactamase. β-lactamase and this gene were first discovered in people who had travelled to India or South Asia in 2008.

Conclusion

NDM-1 is an enzyme that can resist a wide range of antibiotics.

Summary Introduction

To determine:

How NDM-1 coding gene spread among bacteria.

Concept introduction:

NDM-1 (New Delhi metallo-beta-lactamase 1) is an enzyme encoded by plasmid which is able to make bacteria resistant to a wide range of β-lactam antibiotics. This is because the enzyme is able to break the beta-lactam ring of many antibiotics.

Expert Solution
Check Mark

Explanation of Solution

The beta-lactamase coding gene is easily transfers from bacteria to bacteria through horizontal gene transfer. Horizontal gene transfer is also termed as lateral gene transfer. It is the primary means of spread of antibiotic resistance among bacteria. It is a way through which genetic material is transferred between organisms.

Conclusion

blaNDM-1 gene is transferred to other bacteria through horizontal gene transfer.

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Chapter 12 Solutions

Microbiology: A Systems Approach

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