EBK BIOLOGY:SCIENCE F/LIFE
6th Edition
ISBN: 9780134819167
Author: BELK
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Videos
Question
Chapter 12, Problem 4LTB
Summary Introduction
Antibiotics are the drugs that kill microbes including bacteria. Antibiotics are effective in controlling infections through their immune system.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Different strains of Streptococcus pyogenes have different virulence factors, giving these microbes much versatility. Virulence factors include which of the following? Choose one or more:
A.A capsule that, when thick, will help the organism avoid phagocytosis by macrophages
B.A cell wall containing lipoteichoic acid, thought to facilitate adherence to pharyngeal epithelial cells
C.Enzymes that lyse blood cells (streptolysins)
D.The production of several endotoxins called streptococcal pyogenic endotoxins (SPEs)
You are designing a phage therapy for a cystic fibrosis patient with an multi-antibiotic resistant Mycobacterium infection. The Mycobacterium infection is preventing the patient from taking immunosuppressant drugs that are needed for a successful lung transplant. The idea is that introducing the right phage to the patient will kill the Mycobacterium cells and allow the patient to go on immunosuppressant drugs that will ensure the new lung is not rejected by the body.
You need to find a phage that infects the Mycobacterium you isolated from the patient.
Which TWO options have the highest chance of success?
A. Screening a colleague's library of known Mycobacterium phages for phage that infect the patient's Mycobacterium isolate
b. Choosing likely candidates from analysis of phage 16S rRNA phylogeny in the tree of life
C. Isolating new phage from soil using a plaque assay with the Mycobacterium isolate
D. Obtaining a very well-studied phage, such as T4 bacteriophage, that…
You are designing a phage therapy for a cystic fibrosis patient with an multi-antibiotic resistant Mycobacterium infection. The Mycobacterium infection is preventing the patient from taking immunosuppressant drugs that are needed for a successful lung transplant. The idea is that introducing the right phage to the patient will kill the Mycobacterium cells and allow the patient to go on immunosuppressant drugs that will ensure the new lung is not rejected by the body.
You finally find a phage that you think will work because it attaches to and injects its genome into the patient's Mycobacterium isolate. Next, you need to be sure of what characteristics of the phage infection cycle? Pick all that are true
A. That the phage delivers new antibiotic resistance genes to Mycobacterium via transduction
B. That the correct proteins are expressed during the phages metabolism
C. That the infection is lytic
D.That lysogeny is the primary infection pathway
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- You are designing a phage therapy for a cystic fibrosis patient with an multi-antibiotic resistant Mycobacterium infection. The Mycobacterium infection is preventing the patient from taking immunosuppressant drugs that are needed for a successful lung transplant. The idea is that introducing the right phage to the patient will kill the Mycobacterium cells and allow the patient to go on immunosuppressant drugs that will ensure the new lung is not rejected by the body. You need to find a phage that infects the Mycobacterium you isolated from the patient. Which TWO options have the highest chance of success? Group of answer choices 1.Isolating new phage from soil using a plaque assay with the Mycobacterium isolate 2.Choosing likely candidates from analysis of phage 16S rRNA phylogeny in the tree of life 3.Obtaining a very well-studied phage, such as T4 bacteriophage, that specifically targets E. coli 4.Screening a colleague's library of known Mycobacterium phages for phage that…arrow_forwardWhat cells inside our bodies would be affected if you ingested a suspension of T4 phage? Describe and explain the difference in results if Staphylococcus aureus were used instead of Escherichia coli.arrow_forwardPenicillin was first used in the 1940s to treat gonorrhea infections produced by the bacterium Neisseria gonorrhoeae. In 1984, according to the CDC, fewer than 1% of gonorrhea infections were caused by penicillin-resistant N. gonorrhoeae. By 1990, more than 10% of cases were penicillin resistant and a few years later the level of resistance was 95%. Explain the various ways this resistance could be spread among the cells. Could this resistance pass to other infectious bacteria from N. gonorrhoeae?arrow_forward
- Using the Koch's Postulates, support the findings that Mycobacterium tuberculosis is the causative agent of tuberculosis. Specifically, you have to provide brief narratives/pictures/proofs and sources that support the postulate listed below: The organism must be isolated from the newly infected animals and cultured again in the laboratory, after which it should be seen to be the same as the original organism.arrow_forwardAlthough Lilly's project was focused on understanding the prevalence of resistance strains of M. tuberculosis in indigenous populations, she also knew that many patients infected with TB do not have an active disease, ie that the bacteria is latent in the infected lungs. M. tuberculosis is transmitted indirectly via air droplets that are inhaled in the large and small airways. In fact, although 30% of individuals exposed to the bacteria will develop an infection, only 5-10% will develop clinical manifestations. This means 20-25% of people exposed to the bacteria will have a latent disease. Although people with latent disease are not infectious and will not transmit the disease to other community members, latent disease is difficult to diagnose. This was really playing on Lilly's mind, thinking about the difficulty of controlling the spread of the bacteria when most infected people were asymptomatic for years and then suddenly developed active disease, which could then spread for weeks…arrow_forwardDiscuss why it is important for us to conduct research at the basic level of physiology in order to better understand what makes Mycobacteria latent or grow during an infection so that we can design new and/or better treatment modalities.arrow_forward
- How does Mycobacterium tuberculosis gain access through that preferred portal of entry Explain how the Mycobacterium tuberculosis is able to evade innate human host defenses that prevent this from occurring. discuss specific components of your pathogen. (Examples may include capsules, cell wall components, exoenzymes, antigenic variation and penetration of the host cell cytoskeleton.)arrow_forwardExplain why a tuberculin skin test on an AIDS (acquired immunodeficiencysyndrome) patient with tuberculosis may show a negative result.arrow_forwardAs part of your job in an international pharmaceutical company you are given the task of: a) Developing a cheaper method for the production of vitamin C b) Developing a live cholera vaccine Describe how you would accomplish these tasksarrow_forward
- In a case study, scientists frequently infer that Malignant transformation of hymenolepis nana in human host occurred because of the patient’s HIV/AIDS status and resultant immunocompromised state. When N=1, is such an inference statistically justified? In addition to Yes or No, jot down your thoughts on the possible association between AIDS and this case.arrow_forwardMycobacterium tuberculosis recruits phagocytes to the site of infection. Based on this information, which of the three methods shown here does the bacterium likely use to avoid being destroyed?arrow_forwardIn 2013, there was an outbreak of methicillin-resistant Staphylococcusaureus (MRSA) at an NFL training facility. One player suffereda career-ending infection to his foot and sued the team owners for $20 million for unsanitary conditions that contributed to the bacterialinfection. A settlement with undisclosed terms was reached in2017. MRSA is highly contagious and is spread by direct skin contactor by airborne transmission and can result in amputation or death.In addition, MRSA is very difficult to treat because it is resistant tomany antibiotics. For example, b -lactam antibiotics, such as penicillin,function by binding to and inactivating bacterial penicillin-bindingproteins (PBPs), which synthesize the bacterial cell wall. However,MRSA expresses an alternative type of PBP, called PBP2a encodedby the mecA gene. b -lactam antibiotics only weakly bind PBP2a,and thus cell wall synthesis can continue in their presence. Moreover,in a system somewhat analogous to the regulation of the…arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Bacterial Infections in Humans; Author: Professor Dave Explains;https://www.youtube.com/watch?v=FeFKAl9KyMg;License: Standard Youtube License