Essential Cell Biology (fifth Edition)
Essential Cell Biology (fifth Edition)
5th Edition
ISBN: 9780393680362
Author: ALBERTS, Bruce, Hopkin, Karen, Johnson -
Publisher: W. W. Norton & Company
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Chapter 13, Problem 2Q
Summary Introduction

To explain: The role of Arsenate compound instead of phosphate in glycolysis causes a toxic effect for the cell.

Concept introduction: The arsenate ion ( AsO43- ) chemically resembles with phosphate in many respects. It is also used as an alternative substrate by many phosphate-requiring enzymes. In water, an anhydride bond between arsenate and carbon is quickly hydrolyzed non-enzymatically. In glycolysis, the energetically unfavorable reaction is driven by a pair of coupled reaction for the formation of ATP in step 6 and step 7 as energy generation phase.

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