Chapter 13, Problem 4Q

Summary Introduction

(A)

To write:

Why an inherited deficiency in complement components C3 or C4 can result in less efficient clearance of immune complexes from blood and lymph than normal.

Introduction:

The C3 component of the complement system is an opsonin that promotes the activity of phagocytes. It helps in the formation of pus (pyogenic effect). The C4 is a glycoprotein involved in inflammatory responses and is called an anaphylatoxin. Their deficiencies cause some major immune diseases.

Summary Introduction

(B)

To write:

To highlight what clinical symptoms the above can lead to.

Introduction:

In general, the inherited deficiency of complement components lead to accumulation of immune complexes in the body. They include systemic lupus erythematosus, vasculitis, glomerulonephritis and others.

Summary Introduction

(C)

To write:

To mention and explain the only known effect of deficiencies in complement components C5-C9

Introduction:

The deficiencies of C5-C9 complement components makes one predisposed to infection by Neisseria.