Molecular Cell Biology
Molecular Cell Biology
8th Edition
ISBN: 9781464183393
Author: Harvey Lodish, Arnold Berk, Chris A. Kaiser, Monty Krieger, Anthony Bretscher, Hidde Ploegh, Angelika Amon, Kelsey C. Martin
Publisher: W. H. Freeman
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Chapter 13, Problem 5RTC
Summary Introduction

To write:

The types of genes are altered during the altering of gene expression by the unfolded protein response (UPR) that causes the lowering of the abundance of the unfolded proteins.

How the ER-associated degradation (ERAD) pathways identify the misfolded proteins.

How the reason for the necessity of disloca0tion of misfolded proteins to the cytoplasm.

Introduction:

As the age increases, the thermodynamics and mutations along with some external factors combine against the organisms. It results in the proteins misfolding. Endoplasmic-reticulum associated protein degradation or ERAD shows a cellular pathway that attacks the misfolded proteins of the ER. It leads to subsequent degradation and ubiquitination by a protein-degrading complex.

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