Essentials of Genetics (9th Edition) - Standalone book
9th Edition
ISBN: 9780134047799
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Textbook Question
Chapter 15, Problem 9PDQ
Explain why catabolite repression is used in regulating the lac operon and describe how it fine-tunes β-galactosidase synthesis.
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Describe the mechanism by which cAMP receptorprotein (CRP), the regulatory protein for catabolite repression, functions. Use the lactose operon as an example.
Describe the role of the CRP–cAMP complex in positiveregulation of the lactose operon in E. coli.
Explain why inactivation of the O1 sequence of the lac operator almost completely abolishes repression of the lac operon.
Chapter 15 Solutions
Essentials of Genetics (9th Edition) - Standalone book
Ch. 15 -
CASE STUDY | A mysterious muscular dystrophy
A...Ch. 15 -
CASE STUDY |A mysterious muscular dystrophy
A...Ch. 15 -
CASE STUDY |A mysterious muscular dystrophy
A...Ch. 15 -
HOW DO WE KNOW?
1. In this chapter, we have...Ch. 15 -
2. Review the Chapter Concepts list on p. 280....Ch. 15 - Describe which enzymes are required for lactose...Ch. 15 - Contrast positive versus negative regulation of...Ch. 15 -
5. Both attenuation and riboswitches rely on...Ch. 15 - For the lac genotypes shown in the accompanying...Ch. 15 -
7. For the genotypes and conditions (lactose...
Ch. 15 -
8. The locations of numerous lacI– and lacIs...Ch. 15 - Explain why catabolite repression is used in...Ch. 15 - Describe experiments that would confirm whether or...Ch. 15 - Predict the level of genetic activity of the lac...Ch. 15 - Predict the effect on the inducibility of the lac...Ch. 15 -
13. Describe the role of attenuation in the...Ch. 15 -
14. In a theoretical operon, genes A, B, C, and D...Ch. 15 - A bacterial operon is responsible for production...Ch. 15 - A marine bacterium is isolated and is shown to...Ch. 15 -
17. Why is gene regulation more complex in a...Ch. 15 -
18. List and define the levels of eukaryotic gene...Ch. 15 -
19. Distinguish between the cis-acting regulatory...Ch. 15 - Prob. 20PDQCh. 15 - Compare the control of gene regulation in...Ch. 15 - Many eukaryotic promoter regions contain CAAT...Ch. 15 -
23. What is RNA-induced gene silencing in...Ch. 15 - Although it is customary to consider...Ch. 15 - DNA methylation is commonly associated with a...Ch. 15 - The interphase nucleus appears to be a highly...Ch. 15 - It has been estimated that at least two-thirds of...
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- Explain the role of CAP and cAMP in the regulation of the lac-operon.arrow_forwardDescribe the binding of RNA polymerase, repressors, andactivators to the lac operon when both lactose and glucose are scarce. What is the effect of these scarcities ontranscription of the lac operon?arrow_forwardWhy it is essential to the positive stimulation of transcription of the lac operon ?arrow_forward
- Explain the process of attenuation in the trp operon under the following conditions: (i) No tryptophan (ii) High tryptophan levelsarrow_forwardExplain the process of attenuation of the trp operon under high tryptophan levels.arrow_forwardExplain how the data shown indicate that two operator sites are necessary for repression of the lac operon. What would the results have been if all three operator sites were required for the binding of lac repressor?arrow_forward
- Draw the structure of lac operon and its action when the following conditions are prevailing in the media: increased glucose, low glucose, higher c-AMP, low c-AMP, higher glucose, and high c-AMP, low glucose and High c-AMP, Higher glucose and higher allolactosearrow_forwardExplain why (a) inactivation of the O2 or O3 sequence of the lac operon causes only a twofold loss in repression, and (b) inactivation of both O2 and O3 reduces repression ∼70-fold.arrow_forwardIn terms of the efficient use of bacterial resources, explain why it is necessary for lac operon expression to be controlled both by the lac repressor and by a cyclic AMP receptor protein rather than just by the lac repressor alone.arrow_forward
- Describe the regulation of the lac operon when lactose is present and glucose is absentarrow_forwardDescribe the probable genetic defect that abolishes the sensitivity of the lac operon to the absence of glucose when other metabolic operons continue to be sensitive to the absence of glucose.arrow_forwardBy using separate labelled diagrams, describe as detail as possile the actions of the normal and mutated lac operon in absence of lactose.arrow_forward
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