Concept explainers
To determine: The reason for the rate of fixation of neutral mutations independent of
Introduction: Synonymous substitution is a type of substitution that does not change the encoded amino acid. It is also called a silent substitution. On the contrary, nonsynonymous substitution changes the amino acid sequence encoded by a gene. It is also known as nonsense substitution.
To describe: The rate of fixation of neutral mutations does not depend on the population size with the help of mathematical expression.
Introduction: If a given amino acid position undergoes positive selection for a change, the observed rate of nonsynonymous substitutions in the corresponding DNA sequences is expected to exceed the rate of synonymous substitutions.
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