Genetics: A Conceptual Approach
Genetics: A Conceptual Approach
6th Edition
ISBN: 9781319050962
Author: Benjamin A. Pierce
Publisher: W. H. Freeman
Question
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Chapter 15.4, Problem 38AQP
Summary Introduction

To determine:

Whether the Non-sense mediated mRNA (NMD) decay would pose a problem for the type of treatment given in question. Give reasons.

Introduction:

Non-sense mediated mRNA decay (NMD) is a technique evolved by the eukaryotic cells to prevent the formation of aberrant proteins resulting from nonsense mutations. NMD facilitates the rapid elimination of mRNA that contains premature termination codons. This mechanism does not take place in bacteria. NMD does not affect transcription, but translation ends prematurely due to the encounter of stop codon.

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