Genetics: Analysis and Principles
5th Edition
ISBN: 9780073525341
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 16.3, Problem 1COMQ
When mice carrying the
allele exhibit a darker coat, this
a. a greater level of DNA methylation and a decrease in the expression of the Agouti gene.
b. a lower level of DNA methylation and a decrease in the expression of the Agouti gene.
c. a greater level of DNA methylation and the overexpression of the Agouti gene.
d. a lower level of DNA methylation and the overexpression of the Agouti gene.
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Suppose that you are studying the role of Protein B, which you believe plays a role in regulating PCD/Apoptosis in mice. You create two lines of mutant mice. One (bb) is homozygous for a loss-of-function allele of gene B. The other (Bb) is heterozygous, with one wild-type allele and one loss-of function allele. Initially you pay particular attention to two phenotypes of the resulting mice:(i) The morphology of their paws (see picture) (ii) The size of their brains & shape of their skulls. The bb mice have unusually large brains and unusual protrusions from their skulls. Based on these data, does it appear that Protein B, when present and active, favors or inhibits PCD/Apoptosis?Briefly explain your reasoning. The answer should address both the paw and brain/skull data.
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a. What is the Raly gene? What does it encode? How does it relate to the lethality of Ay?
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c. Explain why there is a non-Mendelian 2:1 yellow/agouti phenotypic ratio in this cross.
Chapter 16 Solutions
Genetics: Analysis and Principles
Ch. 16.1 - Which of the following are examples of molecular...Ch. 16.1 - 2. An epigenetic modification to a specific gene...Ch. 16.1 - Prob. 3COMQCh. 16.1 - Epigenetic changes may a. be programmed during...Ch. 16.2 - 1. For the Igf2 gene, where do de novo methylation...Ch. 16.2 - 2. For XCI to occur, where are the Xist and Tsix...Ch. 16.2 - 3. Which of the following possibilities could...Ch. 16.3 - 1. When mice carrying theallele exhibit a darker...Ch. 16.3 - Which of the following types of epigenetic changes...Ch. 16.4 - Prob. 1COMQ
Ch. 16.4 - Prob. 2COMQCh. 16.4 - Prob. 3COMQCh. 16.4 - Prob. 4COMQCh. 16 - Prob. 1CONQCh. 16 - List and briefly describe five types of molecular...Ch. 16 - Prob. 3CONQCh. 16 - What is the key difference between cis and...Ch. 16 - Prob. 6CONQCh. 16 - Prob. 7CONQCh. 16 - 7. Outline the molecular steps in the process of...Ch. 16 - Prob. 9CONQCh. 16 - 9. In general, explain how epigenetic...Ch. 16 - 10. What are the contrasting roles of trithorax...Ch. 16 - Describe the molecular steps by which polycomb...Ch. 16 - Prob. 13CONQCh. 16 - Using coat color in mice and the development of...Ch. 16 - How can environmental agents that do not cause...Ch. 16 - Prob. 5CONQCh. 16 - Define alternative splicing. What are advantages...Ch. 16 - What is the function of a splicing factor? Explain...Ch. 16 - Figure 16.8 shows the products of alternative...Ch. 16 - Lets suppose a person is homozygous for a mutation...Ch. 16 - Prob. 20CONQCh. 16 - What are the advantages and disadvantages of mRNAs...Ch. 16 - Prob. 22CONQCh. 16 - Prob. 23CONQCh. 16 - Prob. 24CONQCh. 16 - Describe how the binding of the iron regulatory...Ch. 16 - Prob. 1EQCh. 16 - In the experiments described in Figure 16.8,...Ch. 16 - Prob. 3EQCh. 16 - A research study indicated that an agent in...Ch. 16 - Lets suppose you were interested in developing...Ch. 16 - E6. In Experiment 16A by Fire and Mello, were they...Ch. 16 - E7. Explain how the data of Fire and Mello...Ch. 16 - Prob. 8EQCh. 16 - 2. Discuss the similarities and differences of...Ch. 16 - How are regulatory transcription factors...
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