Concepts of Biology
1st Edition
ISBN: 9781938168116
Author: Samantha Fowler, Rebecca Roush, James Wise
Publisher: OpenStax College
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Chapter 17, Problem 18CTQ
Different MHC class I molecules between donor and recipient cells can lead to rejection of a transplanted organ or tissue. Suggest a reason for this.
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In regard to antigen presentation, MHC class I molecules usually present peptides derived from _____, whereas MHC class II molecules usually present peptides derived from _____.
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b. phagolysosome; proteasomes
c. MIIC; self proteins
d. CLIP; HLA-DM
e. endocytic vesicles; endoplasmic reticulum.
the condition aplastic anemia is characterized by complete failure of the bone marrow to produce formed elements of the blood due to damaged hematopoietic stem cells. Explain how aplastic anemia would affect the inmune response
Which of the following interactions will NOT provoke an immune response?
A. Endogenous antigen + MHC Class I + TCR + CD 8+
B. Exogenous antigen + MHC Class II + TCR + CD 4+
C. Exogenous antigen + MHC Class II + BCR
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Chapter 17 Solutions
Concepts of Biology
Ch. 17 - Figure 17.5 Which of the following statements...Ch. 17 - Figure 17.6 Influenza virus is packaged in a viral...Ch. 17 - Figure 17.17 The Rh antigen is found on...Ch. 17 - Which statement is true? a. A virion contains DNA...Ch. 17 - The viral ________ plays a role in attaching a...Ch. 17 - Which statement is true of viral replication? a....Ch. 17 - Which of the following is a barrier against...Ch. 17 - Although interferons have several effects, they...Ch. 17 - Which innate immune system component uses MHC...Ch. 17 - The humoral immune response depends on which...
Ch. 17 - The fact that the body does not normally mount an...Ch. 17 - Foreign particles circulating in the blood are...Ch. 17 - Allergy to pollen is classified as _______. a. an...Ch. 17 - A potential cause of acquired autoimmunity is...Ch. 17 - Autoantibodies are probably involved in ________....Ch. 17 - Why can’t dogs catch the measles?Ch. 17 - Why is immunization after being bitten by a rabid...Ch. 17 - Different MHC class I molecules between donor and...Ch. 17 - If a series of genetic mutations prevented some,...Ch. 17 - How do B and T cells differ with respect to...Ch. 17 - Why is the immune response after reinfection much...Ch. 17 - Some photographers develop a sensitivity to...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- MHC class I molecules present peptide antigens derived from a(n) _______ compartment, whereas MHC class II molecules present peptide antigens derived from a(n) _______ compartment: a. extracellular; intracellular b. intracellular; extracellular c. opsonization; neutralization d. neutralization; opsonization e. none of the above.arrow_forwardMHC class II proteins: A. present exogenous antigen to the immune system B. both are found on antigen presenting cells and present exogenous C. antigen to the immune system are found on antigen presenting cellsarrow_forwardDifferent MHC I molecules between donor and recipient cells can lead to rejection of a transplanted organ or tissue. Explain relevant concepts in relation to tissue rejection in organ transplant.arrow_forward
- Why would a virus that can interfere with a host cell’s production of MHC class I molecules be at an advantage?arrow_forwardA T cell can have TCRs with two different alpha chains. Explain how this can occur and why we typically only see mature T cells with one alpha chain.arrow_forwardAntibodies designed to interact with a specific antigensite are (monoclonal, polyclonal).arrow_forward
- Why is the concentration of this ligand for the NK-cell receptor CD94:NKG2A. on the target cell an effective measure of the presence or absence of classical MHC class I molecules?arrow_forwardThree major cell types, dendritic cells, macrophages, and B cells, present peptides bound to MHC class II molecules for recognition by CD4 T cells. In general, these peptides are derived from proteins or pathogens taken up by the cell by endocytosis, phagocytosis, or macropinocytosis. Based on these pathways of antigen uptake, some of the enzymes that degrade proteins to generate peptides for MHC class II presentation are: Ubiquitin ligases that tag proteins for degradation by the proteasome ATP transporter proteins that deliver endocytic proteins into the cytosol for degradation Cysteine proteases like cathepsins that function at acidic pH The lysosomal thiol reductase found in the endosomes The lysosome-associated membrane trafficking protein, LAMP-2arrow_forwardHuman immunodeficiency virus (HIV) preferentially destroys CD4+ cells. Specifically, what effect does this have on antibody and cell-mediated immunity? Please simple and original response. Thank you (:arrow_forward
- Peptide editing is an important component of antigen presentation for both MHC class I and MHC class II pathways, as it drives the preferential presentation of high-affinity binding peptides. For MHC class II peptide editing, HLA-DM plays a key role. In the absence of HLA-DM: MHC class II molecules traffic to the cell surface with CLIP in their binding sites. No MHC class II molecules are released to traffic to the cell surface. MHC class II molecules bind to HLA-DO and are inhibited from binding peptides. Pathogens can evade the immune system by blocking peptide exchange on MHC class II. HLA-DO competes for high-affinity binding peptides with MHC class II molecules and blocks antigen presentation.arrow_forwardMHC class I proteins: A. both are on all nucleated cells and present endogenous antigens to the immune system B. present endogenous antigens to the immune system C. are on all nucleated cellsarrow_forwardToll-like receptor stimulation in both myeloid dendritic cells and plasmacytoid dentritic cells will result in the upregulation of this molecule in both? Group of answer choices MHC II IL-12 IL-1 TNF-alphaarrow_forward
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