Genetics: A Conceptual Approach
Genetics: A Conceptual Approach
6th Edition
ISBN: 9781319050962
Author: Benjamin A. Pierce
Publisher: W. H. Freeman
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Chapter 17.2, Problem 1TPSQ
Summary Introduction

To determine:

A mechanism for how topoisomerase might stimulate gene expression.

Introduction:

The intertwined double helical nature of DNA sometimes cause winding problem. DNA becomes overwound before replication or transcription and if left in this overwound form, the torsion will eventually prevent the ability of polymerases enzymes involved in replication to continue further down the strands of DNA. Topoisomerase is an enzyme which is responsible for the unwinding of supercoiled DNA.

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