The way in which comparative genomics aid in the identification of genes responsible for a complex human disease like hypertension. Also, justify as to how comparisons of rat and human candidate loci to those in the mouse may help validate the studies. Introduction: Comparative genomics is a field which has many applications in research. Discovery of genes and model organisms are developed using comparative genomics. Hypertension (high blood pressure) is a condition where blood force is high enough against artery walls that it may eventually lead to health problems like heart diseases.

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Chapter 18, Problem 19PDQ

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The way in which comparative genomics aid in the identification of genes responsible for a complex human disease like hypertension. Also, justify as to how comparisons of rat and human candidate loci to those in the mouse may help validate the studies.

Introduction:

Comparative genomics is a field which has many applications in research. Discovery of genes and model organisms are developed using comparative genomics. Hypertension (high blood pressure) is a condition where blood force is high enough against artery walls that it may eventually lead to health problems like heart diseases.

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Researchers in search of loci in the human genome that arelikely to contribute to the constellation of factors leading tohypertension have compared candidate loci in humans and rats[Stoll, M., et al. (2000). New Target Regions for Human Hypertensionvia Comparative Genomics. Genome Res. 10:473–482].Through this research, they identified 26 chromosomal regionsthat they consider likely to contain hypertension genes. Howcan comparative genomics aid in the identification of genesresponsible for such a complex human disease? The researchersstate that comparisons of rat and human candidate loci tothose in the mouse may help validate their studies. Why mightthis be so?