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ORGANIC CHEM. VOL.1+2-W/WILEYPLUS
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- Proteases are enzymes that can break covalent bonds in proteins. Proteases play major roles in the regulation of biological processes, so compounds that inhibit their function, called protease inhibitors, have potential as therapeutic agents. While preparing several potential protease inhibitors, compound 1 was converted into compound 3 via alkyne 2, as shown. (J. Org. Chem. 1989, 54, 3963- 3972) Draw the structure of alkyne 2, and propose reagents for converting 1 into 3. Step 1 Br Br Ph alle Br Br Edit Drawing OH Modify the given structure of 1 to draw alkyne 2. An eraser is available, and you can use the single bond tool to add/remove pi bonds. OH 2 Ph O ell (-10) Ph = 3 OHarrow_forwardTwo substitution products result from the reaction between 3-chloro-3-methyl-1- butene with sodium acetate (CH3COO – Na +) in acetic acid under SN1. Identify the products.arrow_forwardCompound A has the formula C8H8. It reacts rapidly with KMN04 to give CO2 and a carboxylic acid, B (C7H602), but reacts with only 1 molar equivalent of H2 on catalytic hydrogenation over a palladium catalyst. On hydrogenation under conditions that reduce aromatic rings, 4, equivalents of H2 are taken up and hydrocarbon C (C8H16) is produced. What are the structures of A, B, and C. .CO.H COH A A B C OH A CO2H A B QUESTION 6arrow_forward
- (a) Account for the following :(i) Electrophilic substitution reactions in haloarenes occur slowly.(ii) Haloalkanes, though polar, are insoluble in water.(b) Arrange the following compounds in increasing order of reactivity towards SN2 displacement:2-Bromo-2-Methylbutane, 1-Bromopentane, 2-Bromopentanearrow_forwardPyrethrin II and pyrethrosin are two natural products isolated from plants of the chrysanthemum family. Pyrethrin II is a natural insecticide and is marketed as such. Q, Calculate the index of hydrogen deficiency for each of these natural productsarrow_forwardAnswer Q43, 44, 45arrow_forward
- Arrange the alkenes in each set in order of increasing rate of reaction with HI and explain the basis for your ranking. Draw the structural formula of the major product formed in each case. (a) and (b) H3CH₂CHC=CH₂ and (H3C) 2C=CHCH3arrow_forward(b) For the following reactions, draw structures (including any stereoisomers) for the products A-C. 1. LIAIH4 2. H30arrow_forward2. What is (A) and (B)?arrow_forward
- IQ3 نقطة واحدة Name the following heterocyclic ethers (a) إجابتك نقطة واحدة Name the following heterocyclic ethers H. CH,CH3 (d) CH,CH, H. إجابتك نقطة واحدة Name the following heterocyclic ethers -CH3 CH; () Br إجابتك. II >arrow_forwardSharpless epoxidation of allylic alcohol X forms compound Y. Treatment of Y with NaOH and C6H5SH in an alcohol–water mixture forms Z. Identify the structure of Y and draw a mechanism for the conversion of Y to Z. Account for the stereochemistry of the stereogenic centers in Z. Z has been used as an intermediate in the synthesis of chiral carbohydrates.arrow_forwardOximene and myrcene, two hydrocarbons isolated from alfalfa that have the molecular formula C10H16, both yield 2,6- dimethyloctane when treated with H2 and a Pd catalyst. Ozonolysis of oximene forms (CH3)2C = O, CH2 = O, CH2(CHO)2, and CH3COCHO. Ozonolysis of myrcene yields (CH3)2C = O, CH2 = O, (two equiv), and HCOCH2CH2COCHO. Identify the structures of oximene and myrcene.arrow_forward
- Organic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage LearningOrganic And Biological ChemistryChemistryISBN:9781305081079Author:STOKER, H. Stephen (howard Stephen)Publisher:Cengage Learning,
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